Claudia Ress1, Alexander Tschoner1, Christian Ciardi1, Markus W. Laimer1, Julia W. Engl1, Wolfgang Sturm1, Helmut Weiss2, Herbert Tilg3, Christoph F. Ebenbichler1, Josef R. Patsch1, Susanne Kaser1
European Cytokine Network, Vol.21, No.1, pp. 65-70, 2010, DOI:10.1684/ecn.2009.0177
Abstract Background. Matrix metalloproteinases (MMPs) and their specific inhibitors (tissue inhibitor of
metalloproteinases [TIMPs]), are involved in adipogenesis, angiogenesis and remodeling of extracellular matrix.
MMPs and TIMPs have been shown to be associated with various diseases such as neurological disorders, malig-nancies
and cardiovascular disease. MMPs and TIMPs are thought to play a major role in extensive reorganization
of the adipose tissue in obesity. Methods and materials. To test whether significant weight loss alters circulating
MMPs and TIMPs, 18 morbidly obese women, who underwent bariatric surgery for weight loss, were investigated
before and one year after surgery… More >