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Search Results (7)
  • Open Access


    Understanding cell-extracellular matrix interactions for topology-guided tissue regeneration


    BIOCELL, Vol.47, No.4, pp. 789-808, 2023, DOI:10.32604/biocell.2023.026217

    Abstract Tissues are made up of cells and the extracellular matrix (ECM) which surrounds them. These cells and tissues are actively adaptable to enduring significant stress that occurs in daily life. This astonishing mechanical stress develops due to the interaction between the live cells and the non-living ECM. Cells in the matrix microenvironment can sense the signals and forces produced and initiate a signaling cascade that plays a crucial role in the body’s normal functioning and influences various properties of the native cells, including growth, proliferation, and differentiation. However, the matrix’s characteristic features also impact the repair and regeneration of the… More >

  • Open Access


    Vibration of a Two-Layer “Metal+PZT” Plate Contacting with Viscous Fluid

    Zeynep Ekicioglu Kuzeci1,*, Surkay D. Akbarov2,3

    CMC-Computers, Materials & Continua, Vol.74, No.2, pp. 4337-4362, 2023, DOI:10.32604/cmc.2023.033446

    Abstract The present work investigates the mechanically forced vibration of the hydro-elasto-piezoelectric system consisting of a two-layer plate “elastic+PZT”, a compressible viscous fluid, and a rigid wall. It is assumed that the PZT (piezoelectric) layer of the plate is in contact with the fluid and time-harmonic linear forces act on the free surface of the elastic-metallic layer. This study is valuable because it considers for the first time the mechanical vibration of the metal+piezoelectric bilayer plate in contact with a fluid. It is also the first time that the influence of the volumetric concentration of the constituents on the vibration of… More >

  • Open Access


    Toward an optimized strategy of using various airway mucus clearance techniques to treat critically ill COVID-19 patients


    BIOCELL, Vol.46, No.4, pp. 855-871, 2022, DOI:10.32604/biocell.2022.017520

    Abstract Coronavirus disease 2019 (COVID-19) caused by acute respiratory syndrome coronavirus 2 (SARS-Cov-2) is still threatening the human life and society throughout the world. For those critically ill patients, mechanical ventilation (MV) is essential to provide life support during treatment. However, both the virus infection and MV disrupt the balance between secretion and elimination of airway mucus and lead to mucus accumulation in the lung. Postmortem examination verified that the lungs in patients died of COVID-19 are indeed filled with sticky mucus, suggesting a great need to improve airway mucus clearance in critically ill COVID-19 patients. Therefore, it may be helpful… More >

  • Open Access


    Effect of Mechanical Forces on the Behavior of Dental Stem Cells: A Scoping Review of In-Vitro Studies

    Maryam Rezai Rad1, Sadra Mohaghegh2, Farnaz Kouhestani3, Saeed Reza Motamedian4,*

    Molecular & Cellular Biomechanics, Vol.18, No.2, pp. 51-67, 2021, DOI:10.32604/mcb.2021.015136

    Abstract This article is a scoping review of the studies that assessed the effect of mechanical forces on the behavior of dental stem cells (DSCs). PubMed and Scopus searches were done for in-vitro studies evaluating the effect of tension, hydrostatic pressure (i.e., the pressure applied through an incompressible fluid), compression, simulated microgravity, and vibration on DSCs. The following factors were analyzed: osteogenic/odontogenic differentiation, proliferation, adhesion and migration. Articles were reviewed according to the Preferred Reporting Items for Systematic Reviews extension for scoping reviews (PRISMA-ScR) guideline. Included studies were evaluated based on the modified Consolidated Standards of Reporting Trials (CONSORT). A total… More >

  • Open Access


    Sensing Traction Force Induces Cell-Cell Distant Communications for the Rapid Network Assembly of Airway Smooth Muscle Cells

    Mingxing Ouyang1,*, Zhili Qian1, Yang Jin1, Linhong Deng1

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 65-65, 2019, DOI:10.32604/mcb.2019.06642

    Abstract The collective functions at cell population level rely on cell-cell communications with or without direct contacts [1-3]. The long-range biomechanical force propagating across certain scales far beyond single cell size may reserve the capability to trigger coordinative biological responses within cell population [3-5]. Whether and how cells communicate with each other mechanically in a distant manner remains largely to be explored. Airway smooth muscle (ASM) cells are one crucial component in providing mechanical support and contraction force for the bronchial tubes in respiratory system, whereas the mechanical property of ASM is also associated with asthma attack, and during airway hyper-responsiveness,… More >

  • Open Access


    Some Factors That May Determine the Frequency Response of Cells and Tissue to Applied Electrical and Mechanical Forces

    F. X. Hart1

    Molecular & Cellular Biomechanics, Vol.3, No.4, pp. 235-235, 2006, DOI:10.32604/mcb.2006.003.235

    Abstract This article has no abstract. More >

  • Open Access


    Effects of Deformation Rate on the Unbinding Pathway of the MMP8-Aggrecan_IGD Complex in Cartilage

    Deng Li1, Shuwei Chang1,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.120, No.2, pp. 305-318, 2019, DOI:10.32604/cmes.2019.06475

    Abstract Mechanical force plays a critical role in the remodeling and degradation of cartilage tissues. The cartilage tissue generates, absorbs, and transmits mechanical force, enabling specific biological processes in our body. A moderate intensity mechanical force is necessary for cartilage tissue remodeling and the adaptation of biomechanical properties, but a high intensity mechanical force can lead to pathological degradation of cartilage tissue. However, the molecular mechanism of cartilage degradation is still unclear. We use full atomistic simulations with SMD simulations to investigate whether the magnitude of mechanical force affects the unbinding pathway of the MMP8-Aggrecan_IGD complex. We find that when the… More >

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