Kyle Kurpinski1,2,3, Jennifer Park1,2,3, Rahul G. Thakar1,2,3, Song Li1,2
Molecular & Cellular Biomechanics, Vol.3, No.1, pp. 21-34, 2006, DOI:10.3970/mcb.2006.003.021
Abstract Vascular smooth muscle cells (SMCs) populate in the media of the blood vessel, and play an important role in the control of vasoactivity and the remodeling of the vessel wall. Blood vessels are constantly subjected to hemodynamic stresses, and the pulsatile nature of the blood flow results in a cyclic mechanical strain in the vessel walls. Accumulating evidence in the past two decades indicates that mechanical strain regulates vascular SMC phenotype, function and matrix remodeling. Bone marrow mesenchymal stem cell (MSC) is a potential cell source for vascular regeneration therapy, and may be used to generate SMCs to construct tissue-engineered… More >
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