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  • Open Access


    Identification of Btg2 As A Mechanosensitive Gene by Functional Screening Integrative Analyses

    Yao Guo1, Yijiang Song2, Yu Zhang1, Li Yang1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 119-119, 2019, DOI:10.32604/mcb.2019.07134

    Abstract Osteoarthritis (OA), with its high disability and mortality rate, is the most common arthritis throughout the world [1]. Exposure of articular cartilage to excessive mechanical stress is deeply involved in the pathogenesis of osteoarthritis (OA) [2,3]. However, the mechanism of how mechanical stress causes cartilage degradation is not clear yet. Here we report that bioinformatics-based integrative analyses can assist in the study of mechanisms modulated by mechanical stress within OA pathology, and we reveal that B-cell Translocation Gene 2 (BTG2) can be a mechanosensitive gene involved in OA development. We obtained OA-associated differentially expressed genes from human and rat datasets… More >

  • Open Access


    hnRNPK a Possible Mechanosensitive Gene: Its Function in Chondrocytes and Osteoarthritis

    Lucy Wanjiru Njunge1, Andreanne Poppy Estania1, Li Yang1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 94-94, 2019, DOI:10.32604/mcb.2019.07116

    Abstract Mechanical stimulation contributes to the development, homeostasis, integrity and functionality of the articular cartilage by modulating several cellular activities including production and remodeling of extracellular matrix (ECM), chondrocyte differentiation, proliferation and apoptosis. On the other hand, abnormal mechanical strain play a critical role in osteoarthritis (OA) pathogenesis by inducing ECM degradation and chondrocyte apoptosis. Furthermore, deleterious mechanical loading can also stimulates the production of pro-inflammatory mediators such as interleukin 1β (IL-1β) that promote to cartilage degradation, chondrocyte hypertrophy and inflammation [1]. Heterogeneous nuclear ribonucleoprotein K (hnRNPK), a member of the hnRNP family, is implicated in the expression, stabilization and organization… More >

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