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    Effect of Mechanical Pressure on the Thickness and Collagen Synthesis of Mandibular Cartilage and the Contributions of G Proteins

    Min Zhang, Fa-Ming Chen, Yong-Jin Chen∗,‡, Shun Wu, Xin Lv, Rui-Ni Zhao

    Molecular & Cellular Biomechanics, Vol.8, No.1, pp. 43-60, 2011, DOI:10.3970/mcb.2011.008.043

    Abstract To investigate the role of mechanical pressure on cartilage thickness and type II collagen synthesis, and the role of G protein in that process, in vitro organ culture of mandibular cartilage was adopted in this study. A hydraulic pressure-controlled cellular strain unit was used to apply hydrostatic pressurization to explant cultures. The explants were compressed by different pressure values (0 kPa, 100 kPa, and 300 kPa) after pretreatment with or without a selective and direct antagonist (NF023) for the G proteins. After 4, 8 and 12 h of cell culture under each pressure condition, histological sections of the explants were… More >

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