Mustafa Lateef Fadhil Jumaili1,2, Emrullah Sonuç1,*
CMC-Computers, Materials & Continua, Vol.83, No.2, pp. 2947-2969, 2025, DOI:10.32604/cmc.2025.062719
- 16 April 2025
Abstract Alzheimer’s disease (AD) is a significant challenge in modern healthcare, with early detection and accurate staging remaining critical priorities for effective intervention. While Deep Learning (DL) approaches have shown promise in AD diagnosis, existing methods often struggle with the issues of precision, interpretability, and class imbalance. This study presents a novel framework that integrates DL with several eXplainable Artificial Intelligence (XAI) techniques, in particular attention mechanisms, Gradient-Weighted Class Activation Mapping (Grad-CAM), and Local Interpretable Model-Agnostic Explanations (LIME), to improve both model interpretability and feature selection. The study evaluates four different DL architectures (ResMLP, VGG16, Xception, More >