Maximiliano GIRAUD-BILLOUD1,2,*, Claudio M. FADER1,3, Rocío AGÜERO2, Fernando EZQUER4, Marcelo EZQUER4
BIOCELL, Vol.42, No.2, pp. 35-40, 2018, DOI:10.32604/biocell.2018.07010
Abstract Diabetic nephropathy (DN) is the most frequent cause of chronic renal failure. Until now, the
pathophysiological mechanisms that determine its development and progression have not yet been elucidated. In the
present study, we evaluate the role of autophagy at early stages of DN, induced in type 2 diabetes mellitus (T2DM)
mouse, and its association with proximal tubule membrane endocytic receptors, megalin and cubilin. In T2DM
animals we observed a tubule-interstitial injury with significantly increased levels of urinary GGT and ALP, but an
absence of tubulointerstitial fibrosis. Kidney proximal tubule cells of T2DM animals showed autophagic vesicles
larger than those observed… More >
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