ADRIANA L. FERREIRA, GUSTAVO C. PARIS, ALINE DE A. AZEVEDO, ERIKA A. C. CORTEZ, SIMONE N. CARVALHO, LAIS DE CARVALHO, ALESSANDRA A. THOLE*
BIOCELL, Vol.46, No.8, pp. 1807-1813, 2022, DOI:10.32604/biocell.2022.019363
Abstract Mesenchymal stem cells (MSC) have pushed the field of stem cell-based therapies by inducing tissue
regeneration, immunosuppression, and angiogenesis mainly through vesicles and soluble factors release (paracrine
signaling). MSC-extracellular vesicles (MSC-EV) adaptable secretome and homing to injured sites allowed researchers
to unlock a new era of cell-free based therapy. In parallel, nanoparticles (NP) have been explored in contributing to
transport and drug delivery systems, giving drugs desired physical-chemical properties to exploit cell behavior.
However, NPs can be quickly recognized by immune cells and cleared from circulation. In this viewpoint, we explore
how combining both therapeutic strategies can improve efficacy and… More >
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