JIGANG LEI1,#, ZHENYAO XU2,#, SUKE LI1, MENG LI1, ZHIKAI WANG3, PING LI1, JING WANG1, YINGLU CHEN1, XIAOLE SONG1, CHENGJIE REN1, MEIPING SHEN1, CHENGXIANG DAI1,*
BIOCELL, Vol.45, No.3, pp. 537-546, 2021, DOI:10.32604/biocell.2021.014569
Abstract Psoriasis is an autoimmune-related chronic inflammatory disease with an approximate prevalence of 2–3%
around the world, involving increased keratinocyte proliferation. Indeed, Th17 cells and IL-17 play critical roles in the
pathogenesis of psoriasis. The monoclonal antibodies against cytokines have been shown to have effectively
immunosuppressive effects on human psoriasis. However, there are still some patients that have no response to these
treatments. Some patients have even serious side-effects which may affect their life. Mesenchymal stem cells have the
ability of immunosuppressive and anti-inflammatory effects, which may be an alternative therapy with more safety
and efficacy for human psoriasis. Moreover, the… More >
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