VIRGINIA VILLALOBOS1, ERNESTO BONILLA2,4,*, ALAN CASTELLANO3, ERNESTO NOVO1, RALPH CASPERSEN4, DEBORA GIRALDOTH1, SHIRLEY MEDINA-LEENDERTZ4
BIOCELL, Vol.33, No.3, pp. 187-197, 2009, DOI:10.32604/biocell.2009.33.187
Abstract The effect of manganese toxicity on the ultrastructure of the olfactory bulb was evaluated. Male albino mice were injected intraperitoneally with MnCl2 (5 mg/Kg/day) five days per week during nine weeks. The control group received NaCl (0.9%). The olfactory bulbs of five mice from each group were processed for transmission electron microscopy after 2, 4, 6 and 9 weeks of manganese treatment. On week 2, some disorganization of the myelin sheaths was observed. After 4 weeks, degenerated neurons with dilated cisternae of rough endoplasmic reticulum and swollen mitochondria appeared. A certain degree of gliosis with a predominance of astrocytes with… More >
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