JIANBO ZHOU1,2,3, FENG WAN2,4, BIN XIAO5, XIN LI1, CHENG PENG2,*, FU PENG1,3,*
Oncology Research, Vol.32, No.5, pp. 943-953, 2024, DOI:10.32604/or.2023.044775
Abstract Breast and lung cancers are the leading causes of mortality and most frequently diagnosed cancers in women and men, respectively, worldwide. Although the antitumor activity of chalcones has been extensively studied, the molecular mechanisms of isoliquiritigenin analog 2', 4', 4-trihydroxychalcone (metochalcone; TEC) against carcinomas remain less well understood. In this study, we found that TEC inhibited cell proliferation of breast cancer BT549 cells and lung cancer A549 cells in a concentration-dependent manner. TEC induced cell cycle arrest in the S-phase, cell migration inhibition in vitro, and reduced tumor growth in vivo. Moreover, transcriptomic analysis revealed that TEC modulated the activity… More >
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