Chao Liu*†, Min Jian‡, Hong Qi†, Wei-Zheng Mao†
Oncology Research, Vol.27, No.3, pp. 389-397, 2019, DOI:10.3727/096504018X15223159811838
Abstract Recently, microRNAs (miRNAs) have been reported to participate in multiple biological processes. However,
the effects of miR-495 on gastric cancer (GC) remain unclear. The purpose of this study was to explore the
functions of miR-495 in GC cell proliferation, metastasis, and apoptosis. SGC-7901 and BGC-823 cell lines
were transfected with miR-495 mimic, miR-495 inhibitor, and negative controls (mimic control and inhibitor
control). The expressions of miR-495, cell viability, migration, apoptosis, and apoptosis-related factors were
examined by qRT-PCR, trypan blue staining, Transwell, flow cytometry, and Western blot, respectively.
Simultaneously, key factor expression levels of EMT were detected by qRT-PCR and Western… More >
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