J.A. García1,2, J.M. Peña1, S. McHugh2, A. Jérusalem2,3
CMES-Computer Modeling in Engineering & Sciences, Vol.87, No.5, pp. 411-432, 2012, DOI:10.3970/cmes.2012.087.411
Abstract Neuronal growth is a complex process involving many intra- and extracellular mechanisms which are collaborating conjointly to participate to the development of the nervous system. More particularly, the early neocortical development involves the creation of a multilayered structure constituted by neuronal growth (driven by axonal or dendritic guidance cues) as well as cell migration. The underlying mechanisms of such structural lamination not only implies important biochemical changes at the intracellular level through axonal microtubule (de)polymerization and growth cone advance, but also through the directly dependent stress/stretch coupling mechanisms driving them. Efforts have recently focused on modeling approaches aimed at accounting… More >
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