POOJA JAISWAL¹, VERSHA TRIPATHI¹, ANSHUL ASSAIYA², DHARMENDRA KASHYAP³, RAHUL DUBEY⁴, ANAMIKA SINGH⁴, JANESH KUMAR², HEM CHANDRA JHA³, RAJESH SHARMA⁵, AMIT KUMAR DIXIT⁶, HAMENDRA SINGH PARMAR^1,*

BIOCELL, Vol.46, No.12, pp. 2645-2657, 2022, DOI:10.32604/biocell.2022.021754 - 10 August 2022

Abstract Triple-negative breast cancer (TNBC) cell line MDA-MB-231 is known for Warburg metabolism and defects in mitochondria. On the other hand, dipeptidyl peptidase-IV (DPP-IV) inhibitors such as sitagliptin and vildagliptin and GLP-1 agonist exendin-4 are known to improve mitochondrial functions as well as biogenesis, but no study has evaluated the influence of these drugs on mitochondrial biogenesis on metastatic breast cancer cell line. We have recently reported anticancer effects of 5-aminoimidazole-4-carboxamide riboside on MDA-MB-231 cells via activation of AMP-dependent kinase (AMPK), which activates the downstream transcription factors PGC-1α, PGC-1β, or FOXO1 for mitochondrial biogenesis; above-mentioned incretin-based… More >

XINLU GAO^1,2,#, XIUXIU WANG^1,2,#, WENWEN ZHANG^1,2,#, HANJING LI^1,2, FAN YANG^2,3, WENYA MA², YU LIU^1,*

BIOCELL, Vol.46, No.12, pp. 2637-2644, 2022, DOI:10.32604/biocell.2022.021033 - 10 August 2022

Abstract Photobiomodulation (PBM) has been shown to delay the pathological process of heart failure, but the exact mechanism of action is not clear. Mitochondria occupy one-third of the volume of mammalian cardiomyocytes (CMs) and are central transport stations for CM energy metabolism. Therefore, in this study, we explored the regulatory effects of 630 nm light-emitting diodes (LED-Red) on the mitochondria of CMs. The results show that LED-Red-based PBM promotes adenosine triphosphate (ATP) synthesis by upregulating the expression of glycolipid metabolizing enzymes. Correspondingly, there was an improvement in the activity of succinate dehydrogenase (SDH), a key enzyme… More >

Muhammad Umar Nasir¹, Muhammad Adnan Khan^1,2, Muhammad Zubair³, Taher M. Ghazal^4,5, Raed A. Said⁶, Hussam Al Hamadi^7,*

CMC-Computers, Materials & Continua, Vol.73, No.1, pp. 953-963, 2022, DOI:10.32604/cmc.2022.028958 - 18 May 2022

Abstract One of the most difficult jobs in the post-genomic age is identifying a genetic disease from a massive amount of genetic data. Furthermore, the complicated genetic disease has a very diverse genotype, making it challenging to find genetic markers. This is a challenging process since it must be completed effectively and efficiently. This research article focuses largely on which patients are more likely to have a genetic disorder based on numerous medical parameters. Using the patient’s medical history, we used a genetic disease prediction algorithm that predicts if the patient is likely to be diagnosed… More >

ZHENGGANG XU^1,2,3, LIANG WU³, JIAHAO CHEN¹, YUNLIN ZHAO³, CHONGXUAN HAN¹, TIAN HUANG², GUIYAN YANG^1,*

BIOCELL, Vol.46, No.7, pp. 1733-1746, 2022, DOI:10.32604/biocell.2022.015784 - 17 March 2022

Abstract Darwin’s finches are the most classic case of evolution. Early studies on the evolution of this species were mainly based on morphology. Until now, the mitochondrial genome of Geospiza magnirostris has been sequenced and the study explored the characteristics of the complete genome of G. magnirostris and verified the evolutionary position of it. The 13 PCGs initiated by ATN codons. The stop codons of three PCGs (ND2, COX3 and ND4) were incomplete, with only T- or TA- replacing complete form TAA or TAG. All the tRNA genes expressed a typical cloverleaf secondary structure, except for tRNA^Ser1(AGY), whose dihydrouridine (DHU)… More >

Eduardo-Antonio Trillo-Hernández¹, Arturo Duarte Sierra², Martín Ernesto Tiznado-Hernández^1,*

Phyton-International Journal of Experimental Botany, Vol.91, No.5, pp. 905-913, 2022, DOI:10.32604/phyton.2022.018118 - 24 January 2022

Abstract

The interaction between the nucleus and the different organelles is important in the physiology of the plant. Reactive oxygen species (ROS) are a by-product of the oxidation of organic molecules to obtain energy by the need to carry out the electron transfer between the different enzymatic complexes. However, they also have a role in the generation of what is known as retrograde signaling. This signal comes from the different organelles in which the oxidation of molecules or the electron transference is taking place such as mitochondria and chloroplasts. Furthermore, ROS can also induce the release

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Xiaoshan Guo^1,2, Dandan Huang², Siyu Wen², Yang Bai², Shuhua Zhu^2,*, Jianrong Feng^1,*

Phyton-International Journal of Experimental Botany, Vol.91, No.2, pp. 409-427, 2022, DOI:10.32604/phyton.2022.018022 - 26 September 2021

Abstract Low-temperature storage is convenient for postharvest preservation of peach fruit, but peach fruit is sensitive to cold damage, which lowers its quality. Nitric oxide (NO) has the potential to improve the bitter resistance of peach fruit. In this work, peach fruit was treated with 15 μmol L⁻¹ NO and 5 μmol L⁻¹ c-PTIO [2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxo-3-oxide], to study changes in mitochondrial fatty acids and expression of the C-repeat binding factor (CBF). The results showed that 15 μmol L⁻¹ exogenous NO significantly maintained fruit quality, reduced peroxidation of mitochondrial fatty acids, increased the activities of the antioxidants superoxide dismutase (SOD),… More >

HUAMIN WANG^1,#, YANTING WU^1,#, ZHENLEI WANG^2,#, YUHANG CHEN¹, JINYU MO¹, WEN GUAN¹, YALI ZHANG¹, HONGLIANG YAO^1,*

Oncology Research, Vol.29, No.3, pp. 201-215, 2021, DOI:10.32604/or.2022.03553 - 01 August 2022

Abstract LncRNAs and metabolism represents two factors involved in cancer initiation and progression. However, the interaction between lncRNAs and metabolism remains to be fully explored. In this study, lncRNA FEZF1-AS1 (FEZF1- AS1) was found upregulated in colon cancer after screening all the lncRNAs of colon cancer tissues deposited in TCGA, the result of which was further confirmed by RNAscope staining on a colon tissue chip. The results obtained using FEZF1- AS1 knockout colon cancer cells (SW480 KO and HCT-116 KO) constructed using CRISPR/Cas9 system confirmed the proliferation, invasion, and migration-promoting function of FEZF1-AS1 in vitro. Mechanistically, FEZF1-AS1… More >

YIBIN RUAN¹, ZHONGMING XIE², QIONG LIU², LIXIAO ZHANG², XIKUI HAN², XIAOYAN LIAO², JIAN LIU^1,*, FENGGUANG GAO^2,*

BIOCELL, Vol.45, No.4, pp. 1059-1067, 2021, DOI:10.32604/biocell.2021.015261 - 22 April 2021

Abstract Nicotine and menthol, agonists of nicotinic acetylcholine receptor (nAChR) and transient receptor potential melastatin type 8 (TRPM8), serve important roles in the prevention of cell death-involved neurodegenerative diseases. However, the potential synergistic effects of nicotine and menthol on anti-apoptotic ability are still uncertain. In the present study, the potential synergistic effects of nicotine and menthol on cisplatin or amyloid β_1-42 induced cell model of the neurodegenerative diseases were explored by assessing cell viability, TNF-α expression, caspase-3 activation, and the collapse of mitochondrial membrane potential in human SH-SY5Y neuroblastoma cells. Statistical significance was tested using Student’s t-test… More >

HAN NIU^1,#, XIN CHEN^1,#, XUEQI FU¹, JINGTIAN ZHANG¹, GUODONG LI⁴, YUXIANG WANG¹, JIAYUE SONG¹, XUETING MA¹, CHEN HU⁵, XUEMIN XU³, FUQIANG ZHANG^2,*, LINLIN ZENG^1,*

BIOCELL, Vol.45, No.4, pp. 963-970, 2021, DOI:10.32604/biocell.2021.015297 - 22 April 2021

Abstract Amyotrophic lateral syndrome (ALS) is a progressive degenerative disorder characterized by motor neuron death and axon degeneration. Mitochondrial dysfunction plays a key role in the pathogenesis of ALS, the mechanism of which remains poorly understood. The B-cell lymphoma-2 (Bcl-2) family of proteins that control and mediate mitochondrial function and apoptosis, including the pro-apoptotic members Bcl2-Associated X (Bax), are involved in ALS development. The death receptor 6 (DR6) regulates motor neuron death in ALS, and DR6 antibodies can prevent axon degeneration and motor neuron damage by blocking DR6. Previous studies demonstrated that PSAP localized to mitochondria More >

Xiaolin Wu, Lanping Diao, Guimin Zhao, Chen Huang, Yingzhen Yao, Zhe Gao, Lili Wu^*

Oncologie, Vol.23, No.1, pp. 141-148, 2021, DOI:10.32604/Oncologie.2021.014790 - 30 March 2021

Abstract This study aimed to investigate the relationship and diagnostic potential between microsatellite instability (MSI) caused by a 9-bp GGGGGTAGA insertion/deletion in mitochondrial DNA (mtDNA) at position 8272 and clinical features in Chinese patients diagnosed with non-Hodgkin’s lymphoma. The 9-bp GGGGGTAGA insertion/deletion in the non-d-loop area of the mitochondrial DNA at the 8272 locus was detected by PCR in 139 non-Hodgkin’s lymphoma patient samples. GGGGGTAGA insertion/deletion was found in a total of 16 cases (11.5%), including nine T cell lymphoma and seven B cell lymphoma cases. The 5-year survival rate was 33.3% in patients with non-Hodgkin’s More >