Heba A. S. El-Nashar^1,*, Ahmed T. Negmeldin^2,3,*, Aziza El Baz⁴, Marizé Cuyler⁵, Brandon Alston⁵, Namrita Lall^5,6,7, Naglaa S. Ashmawy^1,8,*

Phyton-International Journal of Experimental Botany, Vol.94, No.10, pp. 3269-3281, 2025, DOI:10.32604/phyton.2025.067998 - 29 October 2025

Abstract Pimenta dioica is a tropical Caribbean tree belonging to the family Myrtaceae, widely used in various human activities, including perfume production, food flavoring, natural pesticides, and medicine. This study aimed to explore the chemical composition of Pimenta dioica flower essential oil obtained via hydrodistillation using GC-MS analysis. Additionally, the oil’s tyrosinase inhibitory activity was investigated. The effectiveness of the oil’s major constituents in binding to tyrosinase was also evaluated through molecular docking simulations. GC-MS analysis identified fifteen compounds, with eugenol (70.59%) as the major component, followed by β-myrcene (10.54%), limonene (8.55%), β-ocimene (4.92%), α-phellandrene (1.39%), and linalool… More >

Ting Wei^1,2,#, Pengli Wei^2,3,#, Yalei Wang^1,2, Yaqiu Mao^2,3, Jian Yan², Xiaotong Hu², Zhenze Qi², Xu Cai², Changkai Jia², Zhiyuan Zhao², Bingkun Li², Min Qiao², Yaxin Zou^2,3, Tingting Yang⁴, Shiyang Sun², Xuesong Feng³, Pengyun Li^2,*, Hongzhou Shang^1,*, Zhibing Zheng²

Oncology Research, Vol.33, No.10, pp. 2981-3006, 2025, DOI:10.32604/or.2025.065123 - 26 September 2025

Abstract Objectives: Immunomodulatory drugs (IMiDs), functioning as molecular glue degraders, have been approved for treating various hematological malignancies; however, the inevitable acquired drug resistance resulting from their skeletal similarity and hematological toxicities poses significant obstacles to their clinical treatment. The study aimed to develop degraders with potent efficiency and low toxicity. Methods: Phenotypic profiling, elaborate structure-activity relationships (SAR), rational drug design and degradation profiles investigations, quantitative proteomics analysis and cell-based functional studies, and pharmacokinetic studies were conducted to develop more potent degraders. Results: This study developed novel CRBN-binding moieties through methylene deletion in lenalidomide’s isoindole core. Lead… More > Graphic Abstract

Ahmed Qasem^*

Phyton-International Journal of Experimental Botany, Vol.94, No.3, pp. 809-824, 2025, DOI:10.32604/phyton.2025.062683 - 31 March 2025

Abstract Pimpinella anisum, commonly known as anise, is generally used in both folk medicine and the culinary world. In traditional medicine, it is valued for its digestive, respiratory, and antispasmodic properties. This study aims to examine the volatile compounds and antibacterial effect of P. anisum essential oil (PAEO) as well as for the first time its genotoxicity employing both in vitro and computational approaches. Gas chromatography-mass spectrometry (GC-MS) analysis identified anethole as the principal compound, which comprises 92.47% of PAEO. PAEO was tested for its potential antibacterial properties against Bacillus subtilis ATCC 6633, Listeria innocua ATCC 33090, Staphylococcus aureus ATCC 29213, Klebsiella aerogenes… More >

RIYAD F. ALZHRANI¹, LAMA BINOBAID², ABDULAZIZ A. ALORAINI¹, MESHAL S. ALSAHLI¹, AHMED H. BAKHEIT³, HANADI H. ASIRI³, SABRY M. ATTIA², ALI ALHOSHANI², GAMALELDIN I. HARISA^1,*

Oncology Research, Vol.33, No.4, pp. 919-935, 2025, DOI:10.32604/or.2024.054537 - 19 March 2025

Abstract Objective: Prostate cancer (PCA) is the second most widespread cancer among men globally, with a rising mortality rate. Enzyme-responsive lipid nanoparticles (ERLNs) are promising vectors for the selective delivery of anticancer agents to tumor cells. The goal of this study is to fabricate ERLNs for dual delivery of gefitinib (GF) and simvastatin (SV) to PCA cells. Methods: ERLNs loaded with GF and SV (ERLNGFSV) were assembled using bottom-up and top-down techniques. Subsequently, these ERLN cargoes were coated with triacylglycerol, and phospholipids and capped with chitosan (CS). The ERLNGFSV, and CS engineered ERLNGFSV (CERLNGFSV) formulations were… More > Graphic Abstract

Amine Batbat^1,2, Mohamed El Fadili³, Naoufal El Hachlafi^4,*, Amine Elbouzidi^5,*, Chaymae Hmimen⁶, Hiba Yahyaoui^2,7, Samir Jeddi⁶, Abdellatif Benbouazza², Kawtar Fikri-Benbrahim⁶, Mohamed Addi⁵, Samiah Hamad Al-Mijalli⁸, Khaoula Habbadi², Hassane Greche¹

Phyton-International Journal of Experimental Botany, Vol.94, No.2, pp. 481-501, 2025, DOI:10.32604/phyton.2025.059841 - 06 March 2025

Abstract This study highlights the regulatory potential antibacterial and antiradical of Origanum elongatum essential oil (EO), an endemic medicinal plant of Morocco used for its various properties. The chemical composition of the EO was characterized using gas chromatography-mass spectrometry (GC-MS). The antibacterial activity against different agricultural phytopathogens was determined by disc diffusion and microatmosphere methods, as well as by the determination of minimum inhibitory concentrations (MIC) and minimum bactericidal concentration (MBC), while the antioxidant activity was evaluated by DPPH and FRAP assays. To complement the experimental analyses, a molecular docking approach was used to predict and elucidate… More >

HASSAN M. OTIFI^*

Oncology Research, Vol.33, No.1, pp. 235-243, 2025, DOI:10.32604/or.2024.055677 - 20 December 2024

Abstract Background: Gastric cancer (GC) remains a global health burden and is often characterized by heterogeneous molecular profiles and resistance to conventional therapies. The phosphoinositide 3-kinase and PI3K and Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathways play pivotal roles in GC progression, making them attractive targets for therapeutic interventions. Methods: This study applied a computational and molecular dynamics simulation approach to identify and characterize SBL-JP-0004 as a potential dual inhibitor of JAK2 and PI3KCD kinases. KATOIII and SNU-5 GC cells were used for in vitro evaluation. Results: SBL-JP-0004 exhibited a robust binding affinity for… More >

SHIMING YE^1,2,#, YUFENG ZHANG^3,#, TING LIU⁴, CONG WANG³, ZHENG YAN⁵, WANDONG SHE^2,*, HAIBING HUA^4,*

BIOCELL, Vol.47, No.9, pp. 1947-1964, 2023, DOI:10.32604/biocell.2023.029333 - 28 September 2023

Abstract Background: Despite its widespread therapeutic use and effectiveness, the underlying pharmacologic mechanisms of Wendan decoction (WDD) and how it works to treat sudden deafness (SD) remain unclear. In this study, the pharmacological mechanisms of WDD underlying SD were analyzed using network pharmacology and molecular docking. Methods: The Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) was employed to identify the active compounds and target genes of WDD, and genes associated with SD were screened on five databases. RGUI conducted Gene Ontology (GO) functional and the Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. A… More >

FENGMEI QIAN^1,2, PEIYAO REN², LI ZHAO², DANNA ZHENG², WENFANG HE³, JUAN JIN^3,*

BIOCELL, Vol.47, No.8, pp. 1853-1867, 2023, DOI:10.32604/biocell.2023.029353 - 28 August 2023

Abstract Background: Diabetic nephropathy (DN) is a serious complication of diabetes with rising prevalence worldwide. We aimed to explore the anti-DN mechanisms of the compound celastrol derived from the medicinal plant Tripterygium wilfordii. Methods: Celastrol-related targets were obtained from Herbal Ingredients’ Targets (HIT) and GeneCards databases. DN-related targets were retrieved from GeneCards, DisGeNET, and Therapeutic Targets Database (TTD). A Protein-protein interaction (PPI) network was established using the Search Tool for the Retrieval of Interacting Genes (STRING) database. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed using ClusterProfiler. The cytoHubba plugin… More > Graphic Abstract

QIAO ZHOU^2,3,4, JIAN LIU^1,2,*, LING XIN¹, YANYAN FANG^1,2, LEI WAN^1,2, DAN HUANG^1,2, JIANTING WEN^1,2

BIOCELL, Vol.47, No.7, pp. 1623-1643, 2023, DOI:10.32604/biocell.2023.028331 - 21 June 2023

Abstract Objective: On the basis of data mining, systematic pharmacology, molecular docking, and experiment validation, the oxidative-inflammatory molecular targets of Coicis Semen in the therapy of osteoarthritis (OA) were explored. Methods: The association rule analysis was effectively applied to highlight the correlation between Coicis Semen and oxidative inflammation indices. The random walk model was subsequently used to evaluate the clinical efficacy of Coicis Semen. Network pharmacology was used to predict network targets. The binding affinity of the active ingredient in Coicis Semen to the key target of OA was also successfully predicted. Results: Coicis Semen showed a significant reduction in oxidative-inflammatory indicators… More >

DER-JEU CHEN, CHENG-HUNG LAI^*

BIOCELL, Vol.47, No.6, pp. 1317-1327, 2023, DOI:10.32604/biocell.2023.028883 - 19 May 2023

Abstract Background: Magnolol, a bioactive extract of the Chinese herb Magnolia officinalis has a protective effect against periodontitis. This study is aimed to explore the mechanisms involved in the functioning of magnolol against periodontitis and provide a basis for further research. Methods: Network pharmacology analysis was performed based on the identification of related targets from public databases. The Protein-protein interaction (PPI) network was constructed to visualize the significance between the targets of magnolol and periodontitis. Subsequently, Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were performed to predict the functions and the signal regulatory… More >