YUE CHEN1, ZHITING TANG2, MIAO YU1, RUI ZHANG1,*, XINXIN DONG1, LIANQUN CAO1
BIOCELL, Vol.44, No.4, pp. 513-524, 2020, DOI:10.32604/biocell.2020.09422
Abstract Preoperative chemoradiation therapy (CRT) is becoming the standard treatment for patients with locally
advanced rectal cancer. However, individual differences in response to treatment range from a complete response to
complete resistance. Predicting the tumor response to radiotherapy may improve the efficacy of radiotherapy. This
review mainly summarizes recent studies about the molecular biomarkers that can predict the response to
radiotherapy in rectal cancer. These studies have indicated that the molecular markers involved in the response to
radiotherapy mainly include genes related to radiosensitivity, cancer stem cell-related markers, non-coding RNAs
(ncRNAs), single-nucleotide polymorphisms (SNPs) and gene methylation, and other factors including… More >
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