XIAOYU WANG1,2,#,*, TAKESHI YAMAMOTO2,#, MAKOTO KADOWAKI2, YIFU YANG1
BIOCELL, Vol.45, No.2, pp. 395-415, 2021, DOI:10.32604/biocell.2021.012280
Abstract Mast cells are the main effector cells in IgE-associated allergic disorders, and we have reported that mucosal
mast cells (MMCs) play a more important role in the development of food allergy (FA). IgE with antigen or calcium
ionophore stimulation can lead to the activation of MMCs via a calcium-dependent pathway. The purpose of the
present study was to identify gene signatures with IgE/antigen (dinitrophenyl-bovine serum albumin, DNP-BSA) or
calcium ionophore (A23187) on the activation of MMCs. Differentially expressed genes between the two types of
samples were identified with microarray analysis. Gene ontology functional and pathway enrichment analyses of
differentially expressed… More >
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