Mohammed Alshahrani¹, Mohammed Al-Jabbar^1,*, Ebrahim Mohammed Senan^2,3, Fatima Ali Amer jid Almahri⁴, Sultan Ahmed Almalki¹, Eman A. Alshari^3,5

CMES-Computer Modeling in Engineering & Sciences, Vol.143, No.3, pp. 3639-3675, 2025, DOI:10.32604/cmes.2025.064668 - 30 June 2025

Abstract Multiple Sclerosis (MS) poses significant health risks. Patients may face neurodegeneration, mobility issues, cognitive decline, and a reduced quality of life. Manual diagnosis by neurologists is prone to limitations, making AI-based classification crucial for early detection. Therefore, automated classification using Artificial Intelligence (AI) techniques has a crucial role in addressing the limitations of manual classification and preventing the development of MS to advanced stages. This study developed hybrid systems integrating XGBoost (eXtreme Gradient Boosting) with multi-CNN (Convolutional Neural Networks) features based on Ant Colony Optimization (ACO) and Maximum Entropy Score-based Selection (MESbS) algorithms for early… More >

Alex Kibet^*, Gilbert Langat

Journal of Intelligent Medicine and Healthcare, Vol.3, pp. 1-14, 2025, DOI:10.32604/jimh.2022.062824 - 04 April 2025

Abstract Multiple Sclerosis (MS) is a disease that disrupts the flow of information within the brain. It affects approximately 1 million people in the US. And remains incurable. MS treatments can cause side effects and impact the quality of life and even survival rates. Based on existing research studies, we investigate the risks and benefits of three treatment options based on methylprednisolone (a corticosteroid hormone medication) prescribed in (1) high-dose, (2) low-dose, or (3) no treatment. The study currently prescribes one treatment to all patients as it has been proven to be the most effective on More >

Stephen Ojo¹, Moez Krichen^2,3,*, Meznah A. Alamro⁴, Alaeddine Mihoub⁵, Gabriel Avelino Sampedro⁶, Jaroslava Kniezova^7,*

CMC-Computers, Materials & Continua, Vol.81, No.1, pp. 643-661, 2024, DOI:10.32604/cmc.2024.052147 - 15 October 2024

Abstract Myelin damage and a wide range of symptoms are caused by the immune system targeting the central nervous system in Multiple Sclerosis (MS), a chronic autoimmune neurological condition. It disrupts signals between the brain and body, causing symptoms including tiredness, muscle weakness, and difficulty with memory and balance. Traditional methods for detecting MS are less precise and time-consuming, which is a major gap in addressing this problem. This gap has motivated the investigation of new methods to improve MS detection consistency and accuracy. This paper proposed a novel approach named FAD consisting of Deep Neural Network… More >

H. M. Rehan Afzal^1,2,*, Suhuai Luo¹, Saadallah Ramadan^1,2, Jeannette Lechner-Scott^1,2,3, Mohammad Ruhul Amin³, Jiaming Li⁴, M. Kamran Afzal⁵

CMC-Computers, Materials & Continua, Vol.66, No.1, pp. 977-991, 2021, DOI:10.32604/cmc.2020.012448 - 30 October 2020

Abstract The diagnosis of multiple sclerosis (MS) is based on accurate detection of lesions on magnetic resonance imaging (MRI) which also provides ongoing essential information about the progression and status of the disease. Manual detection of lesions is very time consuming and lacks accuracy. Most of the lesions are difficult to detect manually, especially within the grey matter. This paper proposes a novel and fully automated convolution neural network (CNN) approach to segment lesions. The proposed system consists of two 2D patchwise CNNs which can segment lesions more accurately and robustly. The first CNN network is… More >

Lauren E. Corona¹, Nadia R. Sion², Anne P. Cameron¹, Paholo G. Barboglio Romo¹, John T. Stoffel¹

Canadian Journal of Urology, Vol.27, No.4, pp. 10294-10299, 2020

Abstract Introduction: We sought to investigate whether starting clean intermittent catheterization (CIC) for multiple sclerosis (MS) patients with lower urinary tract symptoms (LUTS) and elevated post-void residual (PVR) would improve urinary quality of life (QoL) and decrease risk of urinary tract infection (UTI).
Materials and methods: We retrospectively reviewed an institutional database for MS patients with PVR > 100 mL and obstructive LUTS. Patients were categorized by subsequent choice of treatment: CIC versus medical treatment. Outcomes compared over 1-year follow up included incidence of UTI, urinary QoL, emergency room visits, and adherence to therapy.
Results: Between 2014 and 2017,… More >

Patrick J. Shenot

Canadian Journal of Urology, Vol.26, No.3, pp. 9781-9781, 2019

Abstract This article has no abstract. More >

Senad Kalkan¹, William I. Jaffe², Vannita Simma-Chiang³, Eric S. W. Li⁴, Jerry G. Blaivas³

Canadian Journal of Urology, Vol.26, No.3, pp. 9774-9780, 2019

Abstract Introduction: There is a paucity of data about augmentation cystoplasty (AC) in multiple sclerosis (MS) patients with refractory lower urinary tract symptoms (LUTS). The aim of this study is to evaluate the long term outcomes and morbidity of these procedures in MS patients.
Materials and methods: This is a retrospective observational study of consecutive patients (1984-2017) with MS and refractory LUTS who underwent AC with or without a continent/incontinent abdominal stoma or urinary diversion. Pre and postoperative evaluations included routine labs, videourodynamic studies (VUDS), cystoscopy, and upper tract imaging. Long term outcomes and complications were assessed by… More >

Meng-Wei Lin¹, Feng Yang^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 123-124, 2019, DOI:10.32604/mcb.2019.07343

Abstract This article has no abstract. More >

Athanasios Zachariou¹, Maria Filiponi², Dimitrios Baltogiannis¹, John Giannakis¹, Fotios Dimitriadis³, Panagiota Tsounapi⁴, Atsushi Takenaka⁴, Nikolaos Sofikitis¹

Canadian Journal of Urology, Vol.24, No.6, pp. 9107-9113, 2017

Abstract Introduction: Multiple sclerosis (MS) is the commonest progressive neurological disease affecting young people. With advancing disease, management of neurogenic detrusor overactivity (NDO) based on antimuscarinics may prove inadequate and if based on botulinum toxin, may necessitate clean intermittent self-catheterization. The aim of the study was to evaluate the effectiveness of combined mirabegron and desmopressin administration in the treatment of NDO in patients with MS.
Materials and methods: Sixty patients diagnosed with MS and NDO were evaluated. All had received treatment with solifenacin 10 mg/daily for 3 months and were displeased with the results. Patients were divided in… More >

Wally Mahfouz¹, Gilles Karsenty², Jacques Corcos¹

Canadian Journal of Urology, Vol.18, No.4, pp. 5787-5795, 2011

Abstract Introduction: The first application of botulinum toxin type A (BoNT-A) in urology was its injection into the urinary sphincter to treat neurogenic detrusor-sphincter dyssynergia (DSD) in quadriplegic men. Since that first report by Dyskatra et al in 1988, the results of focal BTA injections into the sphincter, the bladder wall and lately into the prostate have raised the interest of the urology community in this promising new therapeutic modality. This is an evidence-based review of the current indications, techniques and outcomes of BTA injections into the urethral sphincter.
Materials and methods: The Medline database was searched for… More >