Fu-Ping Zhu1,#, Wu-Ping Li1,#, Yin-Sheng Cao1, Zhen-Zhen Cai1, Hang Wu1, Yu-Tong Zhu2,*, Hui Liu3,*
BIOCELL, Vol.49, No.6, pp. 1019-1035, 2025, DOI:10.32604/biocell.2025.062380
- 24 June 2025
Abstract Objective: Limb ischemia-reperfusion injury (LIRI) may lead to tissue necrosis and loss of function, even life-threatening. Our previous study found that Tao-Hong-Si-Wu decoction (THSWD) had some efficacy in treating of LIRI. Quercetin, the major component of THSWD, was selected further to uncover the molecular mechanism underlying its treatment of LIRI. Methods: In this study, myoblasts were isolated from rat gastrocnemius muscle tissue, and an in vitro LIRI model was established. The cell counting kit-8 (CCK-8) and colony formation assay were used to evaluate the impact of quercetin on LIRI-induced myoblast viability and proliferation. Lactate dehydrogenase (LDH)… More >
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