Jiayu Zou1,2,3, Yajie Lu3, Jiaqi Li3, Zhaokai Zhou4,5, Fu Peng3, Pu Qiu2,*, Hailin Tang6, Cheng Peng1,*
Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.071940
- 19 January 2026
Abstract Lung cancer is the most common but fatal malignant tumor worldwide. Patients with lung cancer experienced a relatively low 5-year overall survival rate, and issues such as metastasis and drug resistance remain prominent challenges in its clinical management. Neddylation, a novel type of post-translational modification, was overactivated in lung cancer and was closely associated with its occurrence, development, metastasis, and drug resistance. This review systematically summarizes the biological process of neddylation and deeply explores the latest research progress on how neddylation affects lung cancer cell proliferation, metastasis, and drug resistance mechanisms, with a focus on More >