VEYSEL YÜKSEK1,*, SEMIHA DEDE2, AYŞE USTA3, SEDAT ÇETIN2, MEHMET TAŞPINAR4
BIOCELL, Vol.44, No.2, pp. 263-268, 2020, DOI:10.32604/biocell.2020.09172
Abstract It is known that the high electronegativity of fluorine affects various soft tissues, especially the bone structure in
organisms. Of these tissues are the kidneys, which play an important role in the excretion of fluoride from the body.
Fluoride affects many cellular mechanisms. One of these effects is DNA damage. Our study aimed to investigate the
likely protective effect of cholecalciferol (vitamin D3) on genomic DNA damage-induced NaF depending on
concentration and time. The IC25 and IC50 values of NaF for 3, 12 and 24 h and optimum dose of increase in
proliferation to vitamin D3 through MTT assay in… More >
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