Edward Sutanto1, Rinni Sutanto2, Sara Velichkovikj3, Nikola Hadzi-Petrushev4, Mitko Mladenov4, Dimiter Avtanski5,6,7, Radoslav Stojchevski5,6,8,*
Oncology Research, Vol.34, No.5, 2026, DOI:10.32604/or.2026.076157
- 22 April 2026
Abstract The rapid growth and accessibility of artificial intelligence (AI) and machine learning (ML) have opened many avenues to revolutionize biomedical research, particularly in oncogenesis. Oncogenesis is a hallmark process in the development of cancer, involving the amplification of proto-oncogenes and the subsequent dysregulation of molecular signaling networks. These pathways—including the RAS/RAF/MEK/ERK, PI3K-AKT, JAK-STAT, TGF-β/Smad, Wnt/β-Catenin, and Notch cascades—have been studied extensively in isolation, with major strides achieved in understanding how they drive cancer. However, there are still many considerations regarding how these networks interact. Ongoing studies show that crosstalk among these pathways occurs through feedback… More >