Qiang Li*†1, Qi Liu*1, Wanpeng Cheng*, Huiyan Wei*, Wenqian Jiang*, Fang E*, Yuan Yu*, Jianfeng Jin*, Chaoxia Zou*‡
Oncology Research, Vol.27, No.6, pp. 643-651, 2019, DOI:10.3727/096504018X15415906335771
Abstract Heme oxygenase-1 (HO-1) plays an important role in the progression of several malignancies including breast
cancer. However, its role in breast cancer metastasis is still ambiguous. In this study, we observed the effect of
HO-1 on mouse mammary carcinoma metastasis using the in vivo tumor metastasis model. Our results revealed
that overexpression of HO-1 strongly inhibits the lung metastasis of 4T1 cells. In in vitro analysis, associated
indices for epithelial–mesenchymal transition (EMT), migration, and proliferation of 4T1 cells were evaluated.
The results show that HO-1 inhibits EMT, migration, and proliferation of 4T1 cells. In addition, the Notch1/
Slug pathway is… More >
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