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  • Open Access

    ARTICLE

    Ginsenoside Rg1 protects against ischemia-induced neuron damage by regulating the rno-miRNA-27a-3p/PPARγ axis

    YUE GUAN1,#, TINGTING ZHANG2,#, JIANAN YU3, JIAWEI LIU4, WENYUAN LI5, YUJIA ZHENG6, JIALE WANG3, YUE LIU3, FENGGUO ZHAI2,7,*

    BIOCELL, Vol.47, No.7, pp. 1583-1594, 2023, DOI:10.32604/biocell.2023.028016

    Abstract Background: A preliminary miRNA screening showed that expression levels of rno-miRNA-27a-3p were significantly increased in the serum and brain tissues of rats undergoing cerebral ischemia. In recent years, there is evidence of the protective capacity of the saponins extracted from panax ginseng and its primary active ingredient ginsenosideRg1oncerebral ischemic injury. Methods: Fetal rat neurons (FRNs) were cultured in glucose-and-serum-free medium and exposed to hypoxia to establish a cerebral ischemia model in vitro (oxygen and glucose deprivation model, OGD). Antioxidant indexes (CAT, SOD), inflammatory markers (MPO, TNF-α and IL-6), and the expression of apoptosis and proliferation associated proteins (NF kB-p65, Caspase… More >

  • Open Access

    ARTICLE

    Controllability Conditions of Finite Oscillations of Hyper-Elastic Cylindrical Tubes Composed of a Class of Ogden Material Models

    X.G. Yuan1,2, R.J. Zhang3, H.W. Zhang1

    CMC-Computers, Materials & Continua, Vol.7, No.3, pp. 155-166, 2008, DOI:10.3970/cmc.2008.007.155

    Abstract In this paper, the dynamic inflation problems are examined for infinitely long cylindrical tubes composed of a class of transversely isotropic incompressible Ogden material models. The inner surface of the tube is subjected to a class of periodic step radial pressures relating to time. The influences of various parameters, namely, the material parameters, the structure parameters and the applied pressures, on dynamic behaviors of the tube are discussed in detail. Significantly, for some given material parameters, it is proved that the motion of the tube would present a class of nonlinear periodic oscillations for any given pressures and the amplitude… More >

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