A.D.S.M.R. Pascoala
, P.M. da Silvab,c, M.N.C. Coelho Pinheiroa,d,*
Frontiers in Heat and Mass Transfer, Vol.12, pp. 1-7, 2019, DOI:10.5098/hmt.12.29
Abstract Efforts have been made to obtain new drug formulations in ophthalmologic applications to replace eye drops that are inefficient. Soft contact lenses
have been using as an ophthalmic drug delivery device. Several hydrogels were used to prepare solid matrices with the drug impregnated. Assuming
drug diffusion within polymeric devices as the dominant mechanism in the mass transfer process, simple models were developed to describe drug
release from an ocular delivery device. The timolol maleate (medicine for glaucoma treatment) dissolution profile in the release medium for
methacrylate hydrogels based contact lenses were obtained experimentally and compared with predictions considering one-dimensional and… More >
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