XIAOXU LI, YUN WANG, JUAN FANG, ZHI WANG, XIAOAN TAO, JUAN XIA, BIN CHENG*
BIOCELL, Vol.46, No.2, pp. 441-451, 2022, DOI: 10.32604/biocell.2021.014844
Abstract Head and neck squamous cell carcinoma is the sixth most common tumor worldwide, and half of head and
neck squamous cell carcinoma patients are with oral squamous cell carcinoma (OSCC). 300,000 new cases of OSCC
were reported annually. Even with multi-modality treatment, the prognosis of OSCC remains unsatisfactory. Thus, it
is urgent to discover novel therapeutic targets for OSCC. Some microarray studies have revealed that Keratin 4
(KRT4) is downregulated in OSCC, whereas its role in OSCC development remains unknown. The present study
revealed that KRT4 suppressed OSCC progression by inducing cell apoptosis and inhibiting cell invasion. In addition,
KRT4… More >
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