Jing Li*†, Lian-mei Zhao‡, Cong Zhang‡, Meng Li§, Bo Gao†, Xu-hua Hu†, Jian Cao†, Gui-ying Wang†
Oncology Research, Vol.28, No.1, pp. 51-63, 2020, DOI:10.3727/096504019X15619783964700
Abstract Long noncoding RNAs (lncRNAs) participate in and regulate the biological process of colorectal cancer (CRC)
progression. Our previous research identified differentially expressed lncRNAs in 10 CRC tissues and 10
matched nontumor tissues by next-generation sequencing (NGS). In this study, we identified an lncRNA,
FEZF1 antisense RNA 1 (FEZF1-AS1), and further explored its function and mechanism in CRC. We verified
that FEZF1-AS1 is highly expressed in CRC tissues and cell lines. Through functional experiments, we found
that reduced levels of FEZF1-AS1 significantly suppressed CRC cell migration, invasion, and proliferation
and inhibited tumor growth in vivo. Mechanistically, we discovered that reduced levels… More >
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