MAJA MILOSEVIC1,2, MILOS LAZAREVIC1,2, BOSKO TOLJIC1, MILAN PETROVIC2, MIROSLAV VUKADINOVIC2, ZORAN JEZDIC2, BOBAN ANICIC2, DRAGO JELOVAC2, SVETLANA JOVANOVIC3, JELENA MILASIN1,*
BIOCELL, Vol.45, No.6, pp. 1543-1550, 2021, DOI:10.32604/biocell.2021.015060
Abstract Specific cell subpopulations identified as cancer stem cells (CSCs) can be found in basal cell carcinoma (BCC). Generally, CSCs have a marked trans-differentiation potential that could potentially be used in differentiation therapies. However, there are no studies regarding BCC CSCs multipotency. The aim of the study was to analyze the characteristic of CSCs of BCC with emphasis on their differentiation potential upon specific induction. Specific staining and cell morphology were used for differentiation confirmation, along with the expression analysis of osteogenic (ALP, BSP, Runx2, OCN, BMP2), chondrogenic (COL1 and COL2A1), adipogenic (PPAR-γ) and neurogenic (Nestin and MAP2) markers. BCC CSCs… More >
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