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  • Open Access

    VIEWPOINT

    Osteocyte pericellular and perilacunar matrices as markers of bone–implant mechanical integrity

    RéMY GAUTHIER1,*, HéLèNE FOLLET2, ANA-MARIA TRUNFIO-SFARGHIU3, DELPHINE FARLAY2, NINA ATTIK4,5, SYLVAIN MEILLE1, JéRôME CHEVALIER1, DAVID MITTON6

    BIOCELL, Vol.46, No.10, pp. 2209-2216, 2022, DOI:10.32604/biocell.2022.022290

    Abstract To develop durable bone healing strategies through improved control of bone repair, it is of critical importance to understand the mechanisms of bone mechanical integrity when in contact with biomaterials and implants. Bone mechanical integrity is defined here as the adaptation of structural properties of remodeled bone in regard to an applied mechanical loading. Accordingly, the authors present why future investigations in bone repair and regeneration should emphasize on the matrix surrounding the osteocytes. Osteocytes are mechanosensitive cells considered as the orchestrators of bone remodeling, which is the biological process involved in bone homeostasis. These bone cells are trapped in… More >

  • Open Access

    ARTICLE

    Modified enzymatic collagen digestion-mediated isolation of osteocytes

    WENJUAN XU1, GUANGMING DAI1, YIFEI LYU2, YINING ZHANG1, XIAOLIN TU1,*

    BIOCELL, Vol.46, No.4, pp. 1097-1104, 2022, DOI:10.32604/biocell.2022.017505

    Abstract This study established a method for isolating large numbers of high-purity osteocytes from high-density bone. Bone fragments derived from mice tibia and femurs were alternately digested with type I collagenase and EDTA nine times, and the digested cells and bone chips (BC) were cultured, digested, and passaged when cells were fully grown. The types of cells obtained were identified by morphology, viable cell counts, alkaline phosphatase staining, and biochemical activity analyses, and specific osteocyte and osteoblast markers were evaluated by quantitative real-time polymerase chain reaction. Our results showed that among the cells obtained from the third digestion (fractions 7–9) of… More >

  • Open Access

    ARTICLE

    Integrin Signaling and the Response of Osteocytes to Oscillatory Fluid Flow

    J. B. Litzenberger1, 2, P. Tummala2 , C. R. Jacobs1, 2

    Molecular & Cellular Biomechanics, Vol.3, No.4, pp. 219-220, 2006, DOI:10.32604/mcb.2006.003.219

    Abstract This article has no abstract. More >

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