FEI ZHANG1,2,#, JIANZHONG LAI3,#, RONGHAN HE1,#, YI SHI4, KUN XU5, SHIHAI JIANG1, TANGZHAO LIANG1, WANYU ZHAO5, WEIDA REN5, LEI ZHU6, SONG JIN2,*, KUN WANG1,*
BIOCELL, Vol.46, No.3, pp. 699-709, 2022, DOI:10.32604/biocell.2022.015726
Abstract Circular RNAs (circRNAs) are a novel class of non-coding RNA that have recently shown to have huge
capabilities in the regulation of gene expression at the posttranscriptional level. Growing evidence has indicated that
circRNAs could serve as competing endogenous RNAs (ceRNAs) to sponge microRNAs (miRNAs) and suppress
functions of targeted miRNAs. Osteosarcoma (OS) is the most common malignant primary bone cancer.
Hsa_circ_0002137 is upregulated in OS. However, the role of hsa_circ_0002137 in OS remains unclear. Using miRNA
pull-down assay, we showed that cir_0002137 sponged hsa-miR-1246, and BCL2 apoptosis regulator (BCL2) mRNA
was a potential target of hsa-miR-1246 in human osteosarcoma… More >
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