AMYLLY SANUELLY DA PAZ MARTINS1, SAMARA BOMFIM GOMES CAMPOS2, MARÍLIA OLIVEIRA FONSECA GOULART1,2,3, FABIANA ANDRÉA MOURA4,*
BIOCELL, Vol.45, No.3, pp. 461-481, 2021, DOI:10.32604/biocell.2021.014332
Abstract Inflammatory bowel disease (IBD), which includes Crohn’s disease and ulcerative colitis, has a not yet
completely defined aetiology and is characterized by a progressive chronic inflammation that involves nitroxidative
stress and dysbiosis. Extraintestinal manifestations can occur and affect several organs, including the liver and bile
ducts, joints, skin, eyes, and less frequently, the heart, brain, and kidneys, increasing the risk of morbidity and
mortality. These repercussions may be associated with the activity or severity of IBD. The present review proposes to
report and analyse the participation of dysbiosis and nitroxidative stress in the genesis of extraintestinal
manifestations, aiming to contribute… More >
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