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    PHF8 Plays an Oncogene Function in Hepatocellular Carcinoma Formation

    Hong Ye*, Qing Yang, Shujie Qi*, Hairong Li

    Oncology Research, Vol.27, No.5, pp. 613-621, 2019, DOI:10.3727/096504018X15410353669149

    Abstract Hepatocellular carcinoma (HCC) has high morbidity and mortality rates, and the number of new cases and deaths from liver cancer are increasing. However, the details of the regulation in HCC remain largely unknown. Plant homeodomain finger protein 8 (PHF8) is a JmjC domain-containing protein. Recently, PHF8 was reported to participate in several types of cancer. However, the biological function and clinical significance of PHF8 in HCC remain unknown. In this study, we investigate the role of PHF8 in HCC growth and metastasis. We used bioinformatics analysis and identified the differentially expressed PHF8 in primary HCC… More >

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