Maxwell Sandberg^1,*, Mark Xu¹, Randall Bissette¹, Jacob Malakismail², Niara East³, Robenson Nguyen⁴, Jackson Nowatzke¹, Robert Stratta⁵, Dean Assimos^1,6, Colin Kleinguetl¹

Canadian Journal of Urology, Vol.32, No.6, pp. 633-641, 2025, DOI:10.32604/cju.2025.069091 - 30 December 2025

Abstract Objectives: Donor-gifted nephrolithiasis—the presence of a stone in a donor kidney at the time of transplantation—is rare. Research is limited, and no consensus high-quality evidence guidelines exist, leaving selection criteria and management to individual provider discretion. We aimed to estimate the frequency and analyze patient and graft outcomes of deceased donor (DD) transplant recipients with stones in their kidneys at Wake Forest Baptist Medical Center. Methods: All DD renal transplants or patients receiving most of their care postoperatively after DD renal transplantation at our institution from 1979 to 2025 were reviewed. Stones were considered donor-gifted… More >

Federico Greco^1,2,*, Marco Cataldo³, Valerio D’Andrea^2,4, Luca Pugliese⁵, Andrea Panunzio⁶, Alessandro Tafuri⁶, Bruno Beomonte Zobel^2,4, Carlo Augusto Mallio^2,4

Canadian Journal of Urology, Vol.32, No.5, pp. 433-443, 2025, DOI:10.32604/cju.2025.068390 - 30 October 2025

Abstract Background: Radiogenomics offers a non-invasive approach to correlate imaging features with tumor molecular profiles. This study aims to identify computed tomography (CT) imaging characteristics associated with positive NIPA-like domain containing 4 (NIPAL4) expression in clear cell renal cell carcinoma (ccRCC) and to develop a radiogenomic predictive model to support personalized risk stratification. Methods: A retrospective analysis was conducted on 241 ccRCC patients from The Cancer Genome Atlas (TCGA) and The Cancer Imaging Archive (TCIA) databases. Clinical, pathological, and CT features were compared between NIPAL4-positive and NIPAL4-negative groups. A penalized logistic regression model was built to… More >

Joon Yau Leong^1,*, Vignesh Prasad², Carlos J. Perez Kerkvliet¹, Andrew A. Wagner³, Richard E. Link⁴, Mihir S. Shah¹

Canadian Journal of Urology, Vol.32, No.5, pp. 469-475, 2025, DOI:10.32604/cju.2025.066348 - 30 October 2025

Abstract In recent years, the introduction of the Da Vinci Single Port (SP) robotic platform has opened new doors for the treatment of localized renal masses. This technology, particularly when utilized via a regionalized retroperitoneal (RP) approach, offers several distinct advantages that may improve patient recovery. These advantages include easier access to both anterior and posterior renal tumors, avoidance of the peritoneal cavity with complicating adhesions, and simplified supine positioning, potentially reducing the risk of musculoskeletal or nerve injuries. Yet, the learning curve for RP surgery remains steep due to the unfamiliarity of many surgeons with More >

Dimindra Karki^*, Ghizlane Yaakoubi, Beth Edelblute, Ahmed Aboumohamed^*

Canadian Journal of Urology, Vol.32, No.5, pp. 501-507, 2025, DOI:10.32604/cju.2025.063294 - 30 October 2025

Abstract Background: Epithelioid angiomyolipoma (EAML) is an uncommon renal tumor variant with histologic and radiologic features that can mimic renal cell carcinoma (RCC) on imaging due to the paucity of fat compared to the classic AML. EAML may exhibit aggressive behavior, including local invasion, recurrence, and distant metastases to the liver, lungs, and lymph nodes. Although recent reports suggest that up to one-third of EAML cases may behave malignantly, variability in diagnostic criteria and limited case series contribute to uncertainty regarding its true clinical course. Case Description: This case report describes a 19-year-old female presenting with an… More >

Yuhang Liu¹, Xiaoying Zhuang^1,2,*, Huilong Ren¹

CMES-Computer Modeling in Engineering & Sciences, Vol.144, No.3, pp. 3287-3305, 2025, DOI:10.32604/cmes.2025.070018 - 30 September 2025

Abstract Shallow-buried thick sand strata present considerable local instability risks during diaphragm wall trenching construction. However, this critical issue has not been extensively studied, despite its serious safety consequences. This paper proposes an automatic identification model for shallow-buried thick sand strata, integrating three-dimensional limit equilibrium theory with a genetic algorithm to precisely identify the most potentially dangerous local instability mass and determine its minimum safety factor. The model establishes three undetermined parameters: failure angle, upper boundary, and thickness of the local instability mass. These parameters define the search space for the local instability mass. The effectiveness… More >

Anjali Kariyarath Valappil^1,#, Reshmi Akter^2,#, Muhammad Awais², Dong Uk Yang³, Daehyo Jung², Li Ling⁴, Eun Kim⁵, Kyu Hyeong Yoon⁵, Yoon Ok Lee⁵, Deok Chun Yang^1,2,4,*

BIOCELL, Vol.49, No.9, pp. 1771-1795, 2025, DOI:10.32604/biocell.2025.069145 - 25 September 2025

Abstract Objectives: The phytochemical investigation of traditional herbal medicines holds significant promise for modern drug discovery, particularly in cancer therapy. This study aimed to evaluate the cytotoxicity, apoptosis induction, and immune-modulatory activities of extracts from three herbal medicines with historical use in traditional medicine—Acanthopanax sessiliflorus, Phragmites communis, and Pinus densiflora, as well as their combined extract (GMAS 01/COM), on human lung cancer cells (A549) and normal cell lines, including murine macrophages (RAW 264.7) and human keratinocytes (HaCaT). Methods: Plant extracts were prepared using aqueous extraction, sonication, and rotary evaporation. The total phenolic and flavonoid contents were quantified using the… More >

Wei Hu¹, Dan Xiong^2,*

BIOCELL, Vol.49, No.9, pp. 1711-1731, 2025, DOI:10.32604/biocell.2025.067670 - 25 September 2025

Abstract Objectives: Podocytes undergo epithelial-mesenchymal transition (EMT) and ferroptosis in response to hyperglycemic stimulation. This is considered an important early event in the development and progression of diabetic nephropathy (DN). Rhein is the main active anthraquinone derivative in several common traditional herbal medicines. This study aimed to investigate the protective effects of Rhein on podocyte ferroptosis and EMT. Methods: The mouse glomerular podocyte cell line MPC5 was stimulated with high glucose (HG), Rhein, and the ferroptosis inhibitor ferrostatin-1 (Fer-1). Mechanistic investigations employed plasmids to overexpress and knockdown Sirtuin-1 (SIRT1), solute carrier family 7 member 11 (SLC7A11),… More >

Carlos Suso-Ribera^1,2,*

International Journal of Mental Health Promotion, Vol.27, No.7, pp. 929-951, 2025, DOI:10.32604/ijmhp.2025.065646 - 31 July 2025

Abstract Objectives: Schizophrenia is a profoundly stigmatized mental health condition, characterized by misconceptions that affect societal attitudes, policy development, and the lived experiences of individuals with the condition. This study aimed to develop and validate a multidimensional scale for assessing societal stigma towards schizophrenia, while exploring how demographic factors influence such attitudes. Methods: Drawing on an extensive literature review and consultations, the study identified five domains of stigma: Workplace Capability, Intimate Relationships, Autonomy, Risk Perception, and Recovery. Using a two-phase methodology, a preliminary 38-item scale was administered to 729 participants from the general Spanish population, refining… More >

Lingyun Xiang^*, Xu He, Xi Zhang, Chengfu Ou

CMC-Computers, Materials & Continua, Vol.84, No.2, pp. 2375-2389, 2025, DOI:10.32604/cmc.2025.065804 - 03 July 2025

Abstract Linguistic steganography (LS) aims to embed secret information into normal natural text for covert communication. It includes modification-based (MLS) and generation-based (GLS) methods. MLS often relies on limited manual rules, resulting in low embedding capacity, while GLS achieves higher embedding capacity through automatic text generation but typically ignores extraction efficiency. To address this, we propose a sentence attribute encoding-based MLS method that enhances extraction efficiency while maintaining strong performance. The proposed method designs a lightweight semantic attribute analyzer to encode sentence attributes for embedding secret information. When the attribute values of the cover sentence differ… More >

Jovan Peškanov^1,*, Sandro Bogdanović², Aleksa Vlku¹, Goran Anačkov¹, Boris Radak¹

Phyton-International Journal of Experimental Botany, Vol.94, No.6, pp. 1769-1786, 2025, DOI:10.32604/phyton.2025.065536 - 27 June 2025

Abstract Since its description, the taxon Ophrys sphegodes subsp. grammica has been considered endemic to Greece. The morphological and chorological data of this taxon have been overlooked because the name has been used as a synonym for O. sphegodes subsp. taurica in most publications and online databases. Recently discovered Ophrys populations in Serbia were identified as O. sphegodes subsp. grammica. As these populations represent the northernmost point of distribution of this taxon, we provided data on the morphology, flowering season, and ecology. To determine the taxonomic status of this taxon, we performed comparative morphological analyses, comparing them to other populations of… More >