ZAHRA NASRPOUR NAVAEI1, GHAZALEH KHALILI-TANHA1, AMIR SADRA ZANGOUEI2, MOHAMMAD REZA ABBASZADEGAN3, MEYSAM MOGHBELI1,3,*
Oncology Research, Vol.29, No.4, pp. 235-250, 2021, DOI:10.32604/or.2022.025323
Abstract Chemotherapy is one of the main therapeutic modalities for cancer patients. Cisplatin (CDDP), as one of the
first-line drugs, is of great importance in the chemotherapy of various tumors. However, a significant percentage of cancer
patients are resistant to CDDP treatment. Due to the CDDP side effects on normal tissues, the diagnosis of CDDP
resistance is required to suggest the most efficient therapeutic strategies for cancer patients. Several molecular
mechanisms and signaling pathways are associated with CDDP response. The PI3K/AKT signaling pathway has a
pivotal role in the transmission of extracellular signals into the cells to regulate various pathophysiological processes… More >
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