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  • Open Access

    ARTICLE

    Boundedness and Positivity Preserving Numerical Analysis of a Fuzzy-Parameterized Delayed Model for Foot and Mouth Disease Dynamics

    Muhammad Tashfeen1, Fazal Dayan1, Muhammad Aziz ur Rehman1, Thabet Abdeljawad2,3,4,5,*, Aiman Mukheimer2

    CMES-Computer Modeling in Engineering & Sciences, Vol.141, No.3, pp. 2527-2554, 2024, DOI:10.32604/cmes.2024.056269 - 31 October 2024

    Abstract Foot-and-mouth disease (FMD) is a viral disease that affects cloven-hoofed animals including cattle, pigs, and sheep, hence causing export bans among others, causing high economic losses due to reduced productivity. The global effect of FMD is most felt where livestock rearing forms an important source of income. It is therefore important to understand the modes of transmission of FMD to control its spread and prevent its occurrence. This work intends to address these dynamics by including the efficacy of active migrant animals transporting the disease from one area to another in a fuzzy mathematical modeling… More >

  • Open Access

    ARTICLE

    Temporal and Regional Differences in Congenital Heart Surgery in China (2017–2022): Trends and Implications

    Zheng Guo1, Li Xie2, Ju Zhao3, Xing Hao3, Xiaotong Hou3, Wei Wang1,*

    Congenital Heart Disease, Vol.19, No.4, pp. 341-350, 2024, DOI:10.32604/chd.2024.057403 - 31 October 2024

    Abstract Background: With the decline of birth population and the development of medical technology in China, studies assessing how these changes have affected the adoption of congenital heart disease surgery at the national or regional scale are lacking. Methods: We investigated the status of congenital heart surgery in China in the period from 2017–2022, through investigation of the total rates of cardiac surgeries, cardiopulmonary bypass (CPB), adult congenital heart surgeries (CHS), and pediatric CHS (<18 years old), as recorded by the Extracorporeal Circulation Branch of the Chinese Society of Biomedical Engineering. Subsequently, we evaluated correlations between… More >

  • Open Access

    ARTICLE

    Epidemiological and clinical characteristics of lung cancer in Saudi Arabia: a retrospective study in single oncology center

    YOUSEF KATIB1,*, NASSER MULLA2

    Oncology Research, Vol.32, No.11, pp. 1803-1809, 2024, DOI:10.32604/or.2024.052358 - 16 October 2024

    Abstract Background: Lung cancer (LC) is one of the most common neoplastic diseases and a leading cause of death in Saudi Arabia. Its incidence in Saudi Arabia has increased by more than 3% within two decades. Our study aimed to describe the epidemiological and genetic landscapes of LC in Al-Madinah city in Saudi Arabia. Methods: A retrospective analysis was conducted on the medical records of 65 patients diagnosed with lung cancer between 2015 and 2021 at a single medical oncology center in Al-Madinah city of Saudi Arabia. Results: The mean patients’ age was 59.2 years, with 50… More >

  • Open Access

    PROCEEDINGS

    3D Printing of Electrically Conductive and Degradable Hydrogel for Epidermal Strain Sensor

    Binbin Guo1,2, Hui Ying Yang1,*, Jiaming Bai2,*

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.29, No.4, pp. 1-1, 2024, DOI:10.32604/icces.2024.012673

    Abstract Due to excellent electrical conductivity, stretchability, and biocompatibility, electrically conductive hydrogels have been widely used in flexible wearable strain sensors. Generally, conductive fillers need to be integrated with the hydrogel matrix to impart electrical conductivity. According to the method of composite formation between electronic conductive fillers and hydrogel matrix, conductive hydrogels can be classified into embedded conductive and coated conductive hydrogels. Additionally, due to the intrinsic chemical and physical crosslinking networks, traditional hydrogels are not degradable, resulting in severe environmental pollution problems. Herein, we designed electrically conductive and degradable hydrogels for the epidermal strain sensor… More >

  • Open Access

    ARTICLE

    Effect of Ecotype and Gender on the Variation of Leaf Morphological, Epidermal and Stomatal Traits among Pistacia atlantica Desf.

    Abdelghafour Doghbage1,*, Safia Belhadj2, Hassen Boukerker3, Jean Philippe Mevy4, Thierry Gauquelin4, Alain Tonetto5, Benbader Habib1,6, Arezki Derridj7, Zahra Robã Bouabdelli1, Walid Soufan8, Fathi Abdellatif Belhouadjeb1

    Phyton-International Journal of Experimental Botany, Vol.93, No.9, pp. 2383-2413, 2024, DOI:10.32604/phyton.2024.055528 - 30 September 2024

    Abstract The Atlas pistachio tree is a typically Mediterranean species, which represents an important forest heritage in the arid and semi-arid regions of Algeria. It is deeply rooted in the local population’s culture, making it essential to better understand this species for its conservation and valorization. Through our work on 7 provenances of Pistacia atlantica distributed across different bioclimates in Algeria and based on 28 quantitative and qualitative leaf, trichome, and stomatal traits, it was revealed that the Atlas pistachio tree exhibits significant ecotypic variability linked to its habitat and a high adaptability to extreme conditions in… More >

  • Open Access

    ARTICLE

    A Dynamical Study of Modeling the Transmission of Typhoid Fever through Delayed Strategies

    Muhammad Tashfeen1, Fazal Dayan1, Muhammad Aziz Ur Rehman1, Thabet Abdeljawad2,3,4,5,*, Aiman Mukheimer2

    CMES-Computer Modeling in Engineering & Sciences, Vol.141, No.2, pp. 1419-1446, 2024, DOI:10.32604/cmes.2024.053242 - 27 September 2024

    Abstract This study analyzes the transmission of typhoid fever caused by Salmonella typhi using a mathematical model that highlights the significance of delay in its effectiveness. Time delays can affect the nature of patterns and slow down the emergence of patterns in infected population density. The analyzed model is expanded with the equilibrium analysis, reproduction number, and stability analysis. This study aims to establish and explore the non-standard finite difference (NSFD) scheme for the typhoid fever virus transmission model with a time delay. In addition, the forward Euler method and Runge-Kutta method of order 4 (RK-4)… More >

  • Open Access

    ARTICLE

    Prostate cancer temporal and regional trends in Brazil

    MEHRSA JALALIZADEH1,#, HEVELINE RAYANE MOURA ROESCH1,#, FERNANDO KORKES2, QUOC DIEN-TRINH3, LEONARDO OLIVEIRA REIS1,4,*

    Oncology Research, Vol.32, No.10, pp. 1565-1573, 2024, DOI:10.32604/or.2024.052179 - 18 September 2024

    Abstract Objectives: The Brazilian Unified Health System (Sistema Único de Saúde−SUS) is the universal public healthcare system of Brazil that maintains a nationwide database of its patients. Our primary objective was to analyze regional and temporal trends, while our secondary goal was to establish correlations between states’ health economy status and their prostate cancer (PCa) epidemiology. Methods: We analyzed Brazil’s nationwide data on prostate cancer (PCa) incidence, mortality, and care gathered between 2013 and 2021 by the Information Technology Department of SUS (DATA-SUS), updated monthly using the International Classification of Diseases (ICD-10) code. Results: In the period,… More >

  • Open Access

    ARTICLE

    BTG2 interference ameliorates high glucose-caused oxidative stress, cell apoptosis, and lipid deposition in HK-2 cells

    WENJUAN ZHU1, ZHENGZHENG JU2, FAN CUI2,*

    BIOCELL, Vol.48, No.9, pp. 1379-1388, 2024, DOI:10.32604/biocell.2024.052205 - 04 September 2024

    Abstract Objective: Diabetic nephropathy (DN) is a deleterious microangiopathy of diabetes, constituting a critical determinant of fatality in diabetic patients. This work is purposed to disclose the effects and modulatory mechanism of BTG anti-proliferation factor 2 (BTG2) during the pathological process of DN. Methods: BTG2 expression in kidney tissues of diabetic mice and high glucose (HG)-exposed human proximal tubular cell line HK-2 was assessed with Western blot and RT-qPCR. The diabetic mice model was constructed by streptozotocin injection and confirmed by the blood glucose level beyond 16.7 mmol/L. Hematoxylin and eosin (H&E) staining and measurement of… More >

  • Open Access

    ARTICLE

    Genomic profiling of colorectal cancer in large-scale Chinese patients: amplification and somatic mutations in ERBB2

    YUZHI LIU1,#, EVELYNE BISCHOF2,#, ZHIQIN CHEN1, JIAHUAN ZHOU3, BEI ZHANG4, DING ZHANG4, YONG GAO1,*, MING QUAN1,*

    Oncology Research, Vol.32, No.9, pp. 1429-1438, 2024, DOI:10.32604/or.2024.047309 - 23 August 2024

    Abstract Objectives: Human epidermal growth factor receptor 2 (HER2)-targeted therapies have demonstrated potential benefits for metastatic colorectal cancer (mCRC) patients with HER2 amplification, but are not satisfactory in cases of HER2 mutant CRCs. Methods: Consequently, further elucidation of amplifications and somatic mutations in erythroblastic oncogene B-2 (ERBB2) is imperative. Comprehensive genomic profiling was conducted on 2454 Chinese CRC cases to evaluate genomic alterations in 733 cancer-related genes, tumor mutational burden, microsatellite instability, and programmed death ligand 1 (PD-L1) expression. Results: Among 2454 CRC patients, 85 cases (3.46%) exhibited ERBB2 amplification, and 55 cases (2.24%) carried ERBB2 mutation.… More > Graphic Abstract

    Genomic profiling of colorectal cancer in large-scale Chinese patients: amplification and somatic mutations in ERBB2

  • Open Access

    ARTICLE

    Numerical Analysis of Bacterial Meningitis Stochastic Delayed Epidemic Model through Computational Methods

    Umar Shafique1,*, Mohamed Mahyoub Al-Shamiri2, Ali Raza3, Emad Fadhal4,*, Muhammad Rafiq5,6, Nauman Ahmed5,7

    CMES-Computer Modeling in Engineering & Sciences, Vol.141, No.1, pp. 311-329, 2024, DOI:10.32604/cmes.2024.052383 - 20 August 2024

    Abstract Based on the World Health Organization (WHO), Meningitis is a severe infection of the meninges, the membranes covering the brain and spinal cord. It is a devastating disease and remains a significant public health challenge. This study investigates a bacterial meningitis model through deterministic and stochastic versions. Four-compartment population dynamics explain the concept, particularly the susceptible population, carrier, infected, and recovered. The model predicts the nonnegative equilibrium points and reproduction number, i.e., the Meningitis-Free Equilibrium (MFE), and Meningitis-Existing Equilibrium (MEE). For the stochastic version of the existing deterministic model, the two methodologies studied are transition… More >

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