Yuri A. Piven¹, Danila V. Sorokin², Nastassia A. Varabyeva¹, Alexandra L. Mikhaylova², Fedor B. Bogdanov², Elena V. Shafranovskaya¹, Raman M. Puzanau³, Fedor A. Lakhvich¹, Alexander M. Scherbakov^2,4,*

Oncology Research, Vol.33, No.12, pp. 4049-4072, 2025, DOI:10.32604/or.2025.067832 - 27 November 2025

Abstract Background: The most aggressive forms of breast cancer are characterized by independence from steroid hormones but a strong dependence on growth factors. In such cancer cells, oncogenic receptors, including human epidermal growth factor receptor 2 (HER2), are activated, and their targeted inhibition represents an attractive therapeutic strategy. The study aimed to develop small-molecule potential dual heat shock protein 90 (HSP90)-HER2 inhibitors and evaluate them as anticancer agents in HER2-positive cells. Methods: The research project involved obtaining a series of compounds with potential dual inhibitory activity against HSP90 and HER2 by targeted organic synthesis, which was… More > Graphic Abstract

Abdulbari Bener^1,2,*, Ünsal Veli Üstündağ³, Emir Barışık⁴, Cem Cahit Barışık⁵

Canadian Journal of Urology, Vol.32, No.5, pp. 401-409, 2025, DOI:10.32604/cju.2025.067184 - 30 October 2025

Abstract Objectives: The evidence remains insufficient and controversial for evaluating modifiable parameters—such as vitamin D, calcium, ferritin, and uric acid—as preclinical biomarkers to contribute to the prevention and early diagnosis of prostate cancer, a disease with a prevalence of up to 10%–20% in men over 50 and strongly associated with environmental factors including diet (high in fat and red meat), obesity, physical inactivity, and carcinogen exposure. This study aims to investigate the potential biomarker role of vitamin D, calcium, ferritin, and uric acids in reducing the risk of prostate cancer (PCa). Methods: The case-control design was… More >

Ellen M. Cahill, Ankur U. Choksi, Sharath S. Reddy, Dylan C. H. Heckscher, Katherine Rotker, Stanton C. Honig^*

Canadian Journal of Urology, Vol.32, No.5, pp. 521-527, 2025, DOI:10.32604/cju.2025.064559 - 30 October 2025

Abstract Introduction: Spermatocelectomy is a surgical procedure performed for symptomatic spermatoceles. Published data is limited with respect to recurrence rates, complication rates, and patient satisfaction. The core concept of spermatocelectomy is to identify the communication between epididymis and spermatocele, which can be difficult and may result in spermatocele recurrence. We postulate that a combined spermatocelectomy with epididymectomy will yield a lower rate of recurrence. Methods: A retrospective chart review of patients with symptomatic spermatoceles undergoing spermatocelectomy with or without epididymectomy at our institution was performed. Patients were excluded from epididymectomy if they were interested in fertility… More >

Yi Yan^1,2,#, Min He^1,2,#, Feifeng Mao³, Xinyu Zhang⁴, Liyu Wang⁵, Jingwei Li^1,2,*

Phyton-International Journal of Experimental Botany, Vol.94, No.10, pp. 3003-3021, 2025, DOI:10.32604/phyton.2025.069166 - 29 October 2025

Abstract Houttuynia cordata, a characteristic edible and medicinal plant in southwestern China, is prone to absorbing lead (Pb²⁺). Excessive consumption may lead to Pb²⁺ accumulation in the human body, which has been linked to serious health risks such as neurotoxicity, kidney damage, anemia, and developmental disorders, particularly in children. Therefore, the development of molecular markers associated with Pb²⁺ uptake and the investigation of the plant’s physiological responses to Pb²⁺ pollution are of great significance. In this study, 72 H. cordata germplasms were evaluated for Pb²⁺ accumulation after exogenous Pb²⁺ treatment. A significant variation in Pb²⁺ content was observed among the germplasms, indicating… More >

Yifei Wang, Xiaoxiao Han^*, Miaomiao Yuan, Yangguang Zhao, Wei Zhu, Feng Chen

The International Conference on Computational & Experimental Engineering and Sciences, Vol.33, No.2, pp. 1-1, 2025, DOI:10.32604/icces.2025.012585

Abstract With the advancement of the personalised medicine industry, multi-material targeted drug delivery systems have garnered significant attention due to the higher drug bioavailability and synergistic effects of combined drug therapies. However, the fabrication throughput of such systems often fails to satisfy the demands of clinical applications. Volumetric printing, distinguished by its remarkable capability for rapid fabrication, presents a promising approach for fabricating these systems. Nevertheless, during volumetric printing, formed parts are prone to displacement relative to their intended locations due to variations in ink density, viscosity, and other factors, resulting in geometric distortion and complicating… More >

Yuanyuan Yang^1,2,#, Peipei Zhao^1,2,#, Hepu Chen^1,3, Yixuan Tu⁴, Yujia Zhou², Xu Liu³, Lyly Sreang³, Zhigang Zhou^3,5,*, Jian Tu^1,2,*

Oncology Research, Vol.33, No.11, pp. 3247-3268, 2025, DOI:10.32604/or.2025.066440 - 22 October 2025

Abstract Hepatocellular carcinoma (HCC) is characterized by its highly invasive and metastatic potential, as well as a propensity for recurrence, contributing to treatment failure and increased mortality. Under physiological conditions, the liver maintains a balance in lipid biosynthesis, degradation, storage, and transport. HCC exhibits dysregulated lipid metabolism, driving tumor progression and therapeutic resistance. This review aims to elucidate the roles of fatty acid, sphingolipid, and cholesterol metabolism in HCC pathogenesis and explore emerging therapeutic strategies targeting these pathways. Key findings demonstrate that upregulated enzymes like fatty acid synthase (FASN), acetyl-CoA carboxylase (ACC), enhance de novo lipogenesis and… More >

Pralay Roy¹, Pabitra Kumar Biswas¹, Chiranjit Sain^2,*, Taha Selim Ustun^3,*

Energy Engineering, Vol.122, No.10, pp. 4035-4060, 2025, DOI:10.32604/ee.2025.068989 - 30 September 2025

Abstract This study presents the use of an innovative population-based algorithm called the Sine Cosine Algorithm and its metaheuristic form, Quasi Oppositional Sine Cosine Algorithm, to automatic generation control of a multiple-source-based interconnected power system that consists of thermal, gas, and hydro power plants. The Proportional-Integral-Derivative controller, which is utilized for automated generation control in an interconnected hybrid power system with a DC link connecting two regions, has been tuned using the proposed optimization technique. An Electric Vehicle is taken into consideration only as an electrical load. The Quasi Oppositional Sine Cosine method’s performance and efficacy… More >

Songhua Bei^1,2,#, Qianqian Guo^1,#, Xinglei Wu^1,#, Fan Li^2,#, Yaya Xie³, Xiaohong Zhang^2,*, Li Feng^2,*, Xingxing Zhang^1,3,*

Oncology Research, Vol.33, No.10, pp. 3101-3125, 2025, DOI:10.32604/or.2025.067247 - 26 September 2025

Abstract Background: Ferroptosis is a type of regulated cell death characterized by iron-dependent lipid peroxidation, which has been linked to tumor progression and therapeutic resistance. However, the contribution of lactate metabolism and its receptor, hydroxycarboxylic acid receptor 1 (HCAR1), in ferroptosis regulation in gastric cancer (GC) remains poorly understood. Focusing specifically on its effects on cell proliferation, ferroptosis regulation, and the disruption of lactate-mediated metabolic pathways, the study aimed to clarify the role of HCAR1 in GC progression. Methods: Bioinformatics analysis identified prognostic genes associated with ferroptosis in GC. Receiver operating characteristic (ROC) curves were generated… More >

Liang Yu^1,#, Mingrui Zhao^1,#, Jinhui Liu², Yuqin Yang¹, Lin Zhang², Wenjun Cheng^2,*

Oncology Research, Vol.33, No.10, pp. 3007-3022, 2025, DOI:10.32604/or.2025.065137 - 26 September 2025

Abstract Background: The benefit of adjuvant chemotherapy for stage I ovarian endometrioid carcinoma (OEC) remains controversial. Hence, the study sought to explore its value in stage I OEC patients. Methods: Stage I OEC patients (1988–2018) were identified from the Surveillance, Epidemiology, and End Results (SEER) database. Multivariate Cox analysis was used to control confounders. Logistic regression was used to explore factors associated with adjuvant chemotherapy. Cox regression analysis and Kaplan-Meier curves were used to assess the survival benefits. Single-center clinical data and meta-analysis following PRISMA guidelines provided external validation. Result: Adjuvant chemotherapy correlated with improved survival (Hazard… More >

Edo Bedzra^1,2,*, Herra Javed^3,4, James E. O’Brien^1,2, Taufiek Konrad Rajab^3,4

Congenital Heart Disease, Vol.20, No.4, pp. 441-446, 2025, DOI:10.32604/chd.2025.071035 - 18 September 2025

Abstract A bicuspid aortic valve, from autologous tissue, with growth potential can be constructed using the simple, and reproducible telescoping arterial trunk technique. More >