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  • Open Access

    CASE REPORT

    Bicuspidization Using the Open-Sleeve Technique for Congenital Aortic Stenosis during Infancy

    Toshi Maeda*, Hiroki Ito, Keiichi Hirose, Kisaburo Sakamoto

    Congenital Heart Disease, Vol.19, No.2, pp. 177-183, 2024, DOI:10.32604/chd.2024.050945

    Abstract Congenital aortic stenosis (cAS) frequently requires intervention during the neonatal or infantile period. However, surgical repair is challenging because of the narrow surgical space. We performed bicuspidization using the open-sleeve technique for cAS with a unicuspid aortic valve in two patients. Postoperatively, the patients were doing well without reintervention for the aortic valve for 8 and 6 years, respectively. Their aortic annular diameter increased along with somatic growth. Bicuspidization for neonates or infancy can be performed safely using the open-sleeve technique as its midterm results have been satisfactory. More > Graphic Abstract

    Bicuspidization Using the Open-Sleeve Technique for Congenital Aortic Stenosis during Infancy

  • Open Access

    ARTICLE

    A Study on the Role of Tourism in Enhancing Personal Mental Health in the Post-Epidemic Era

    Ruiqin Tian*, Yue Feng, Lingqi Zhan

    International Journal of Mental Health Promotion, Vol.26, No.4, pp. 325-334, 2024, DOI:10.32604/ijmhp.2023.042827

    Abstract With the advent of the post-epidemic era, a great wave of tourism has been ushered in everywhere. The relationship between tourism and mental health has become a hot topic in society. This paper investigates the enhancement of people’s mental health after tourism through social survey. Using Hangzhou as the sample collection site, this paper conducted a study on the role of tourism in enhancing personal mental health through descriptive analysis, factor analysis and structural equation modeling, and further specifically analyzed the role of mediating variables. The results showed that: (1) The purpose of tourism is to relax and relieve stress,… More >

  • Open Access

    ARTICLE

    Profiles of the Headspace Volatile Organic and Essential Oil Compounds from the Tunisian Cardaria draba (L.) Desv. and Its Leaf and Stem Epidermal Micromorphology

    Wissal Saadellaoui1, Samiha Kahlaoui1, Kheiria Hcini1, Abir Haddada1, Noomene Sleimi2,*, Roberta Ascrizzi3, Guido Flamini3, Fethia Harzallah-Skhiri4, Sondes Stambouli-Essassi1

    Phyton-International Journal of Experimental Botany, Vol.93, No.4, pp. 725-744, 2024, DOI:10.32604/phyton.2024.048110

    Abstract In this work, we investigated aroma volatiles emanated by dry roots, stems, leaves, flowers, and fruits of Cardaria draba (L.) Desv. growing wild in Tunisia and its aerial part essential oils (EOs) composition. A total of 37 volatile organic compounds (96.7%–98.9%) were identified; 4 esters, 4 alcohols, 7 hydrocarbons, 12 aldehydes, 5 ketones, 1 lactone, 1 organosulfur compound, 2 organonitrogen compounds, and 1 acid. The hydrocarbons form the main group, representing 49.5%–84.6% of the total detected volatiles. The main constituent was 2,2,4,6,6-pentamethylheptane (44.5%–76.2%) reaching the highest relative percentages. Forty-two compounds were determined in the two fractions of EOs, representing 98.8%… More >

  • Open Access

    ARTICLE

    Circ_0053943 complexed with IGF2BP3 drives uveal melanoma progression via regulating N6-methyladenosine modification of Epidermal growth factor receptor

    ANDI ZHAO1,2,#, YUE WANG3,#, ZIJIN WANG1,2, QING SHAO1,2, QI GONG1,2, HUI ZHU1,2, SHIYA SHEN1,2, HU LIU1,2,*, XUEJUAN CHEN1,2,*

    Oncology Research, Vol.32, No.5, pp. 983-998, 2024, DOI:10.32604/or.2024.045972

    Abstract Numerous studies have characterized the critical role of circular RNAs (circRNAs) as regulatory factors in the progression of multiple cancers. However, the biological functions of circRNAs and their underlying molecular mechanisms in the progression of uveal melanoma (UM) remain enigmatic. In this study, we identified a novel circRNA, circ_0053943, through re-analysis of UM microarray data and quantitative RT-PCR. Circ_0053943 was found to be upregulated in UM and to promote the proliferation and metastatic ability of UM cells in both in vitro and in vivo settings. Mechanistically, circ_0053943 was observed to bind to the KH1 and KH2 domains of insulin-like growth… More > Graphic Abstract

    <i>Circ_0053943</i> complexed with IGF2BP3 drives uveal melanoma progression via regulating N6-methyladenosine modification of <i>Epidermal growth factor receptor</i>

  • Open Access

    ARTICLE

    Identification prognostic features related to sphingolipid metabolism and experimental validation of TRIM47 in hepatocellular carcinoma

    JIAN TANG1, CHENQIANG ZHU1, YUN CHEN1, YUNLONG WU1, MING HE1, YI ZHOU2, MINGHUA XIE2,*

    BIOCELL, Vol.48, No.4, pp. 639-651, 2024, DOI:10.32604/biocell.2024.047562

    Abstract Background: The specific impact of sphingolipid metabolism on developing hepatocellular Carcinoma (HCC) remains unclear. This study aims to explore the relationship between sphingolipid metabolism and HCC prognosis, immune response, and drug sensitivity. Methods: Data were obtained from The Cancer Genome Atlas (TCGA)-Hepatocellular Carcinoma (LIHC) and Gene Expression Omnibus (GEO, GSE14520 datasets). 47 sphingolipid metabolism genes were obtained from the Kyoto Encyclopedia of Genes and Genomes (KEGG) database. After classifying HCC samples using the Non-negative Matrix Factorization (NMF) clustering method, differentially expressed genes were screened. Then, 8 risk genes were obtained by univariate analysis, survival random forest reduction and lasso analysis.… More > Graphic Abstract

    Identification prognostic features related to sphingolipid metabolism and experimental validation of TRIM47 in hepatocellular carcinoma

  • Open Access

    ARTICLE

    A Rapid Parameter of Enzyme-Treated Cellulosic Material Revealed by Reducing Sugar Release

    Verônica Távilla Ferreira Silva, Adriane Maria Ferreira Milagres*

    Journal of Renewable Materials, Vol.12, No.3, pp. 539-551, 2024, DOI:10.32604/jrm.2023.045726

    Abstract This study was conducted to evaluate the effectiveness of enzymes in purifying and reducing the degree of polymerization of cellulose for the production of dissolving pulp. Our goal was to determine the contributions of xylanase (X) and endoglucanase (EG) in the treatment of pulp, specifically by quantifying the formation of soluble and insoluble reducing sugars using the dinitrosalycilic acid (DNS) test. Predominantly, the release of soluble reducing sugars (RSSol) was enhanced after xylanase treatment, while endoglucanase (EG) treatment led to changes in insoluble reducing sugars (RSIns). The maximum synergism was observed for RSIns when a high ratio of endoglucanase to… More > Graphic Abstract

    A Rapid Parameter of Enzyme-Treated Cellulosic Material Revealed by Reducing Sugar Release

  • Open Access

    ARTICLE

    Relationships among Sedentary Time, Electronic Product Addiction, and Depression in Adolescents during the COVID-19 Epidemic: A Cross-Lagged Study

    Feng Sheng1,*, Chen Kong2, Chao Li3

    International Journal of Mental Health Promotion, Vol.26, No.3, pp. 221-228, 2024, DOI:10.32604/ijmhp.2024.030209

    Abstract Objective: This study was conducted to explore the relationships among sedentary behavior (SB), electronic product addiction (EPA), and depression (D) in adolescents during the COVID-19 epidemic. Methods: A total of 604 adolescents (including 309 girls and 295 boys aged 12–18) were selected from Qufu City, Shandong Province, China for three rounds of investigation. The model was constructed using AMOS 23.0 software, and cross-lagged analysis was conducted. Results: SB at T1 can significantly positively predict SB and EPA at T2 (p < 0.05). EPA at T1 can significantly positively predict SB and D at T2 (p < 0.05). Physical activity level… More >

  • Open Access

    ARTICLE

    A Hybrid SIR-Fuzzy Model for Epidemic Dynamics: A Numerical Study

    Muhammad Shoaib Arif1,2,*, Kamaleldin Abodayeh1, Yasir Nawaz2

    CMES-Computer Modeling in Engineering & Sciences, Vol.139, No.3, pp. 3417-3434, 2024, DOI:10.32604/cmes.2024.046944

    Abstract This study focuses on the urgent requirement for improved accuracy in disease modeling by introducing a new computational framework called the Hybrid SIR-Fuzzy Model. By integrating the traditional Susceptible-Infectious-Recovered (SIR) model with fuzzy logic, our method effectively addresses the complex nature of epidemic dynamics by accurately accounting for uncertainties and imprecisions in both data and model parameters. The main aim of this research is to provide a model for disease transmission using fuzzy theory, which can successfully address uncertainty in mathematical modeling. Our main emphasis is on the imprecise transmission rate parameter, utilizing a three-part description of its membership level.… More >

  • Open Access

    ARTICLE

    Novel Investigation of Stochastic Fractional Differential Equations Measles Model via the White Noise and Global Derivative Operator Depending on Mittag-Leffler Kernel

    Saima Rashid1,2,*, Fahd Jarad3,4

    CMES-Computer Modeling in Engineering & Sciences, Vol.139, No.3, pp. 2289-2327, 2024, DOI:10.32604/cmes.2023.028773

    Abstract Because of the features involved with their varied kernels, differential operators relying on convolution formulations have been acknowledged as effective mathematical resources for modeling real-world issues. In this paper, we constructed a stochastic fractional framework of measles spreading mechanisms with dual medication immunization considering the exponential decay and Mittag-Leffler kernels. In this approach, the overall population was separated into five cohorts. Furthermore, the descriptive behavior of the system was investigated, including prerequisites for the positivity of solutions, invariant domain of the solution, presence and stability of equilibrium points, and sensitivity analysis. We included a stochastic element in every cohort and… More >

  • Open Access

    ARTICLE

    Comparative Study of Genetic Structure and Genetic Diversity between Wild and Cultivated Populations of Taxus cuspidata, Northeast China

    Dandan Wang, Xiaohong Li, Yanwen Zhang*

    Phyton-International Journal of Experimental Botany, Vol.93, No.2, pp. 355-369, 2024, DOI:10.32604/phyton.2024.047183

    Abstract Taxus cuspidata is a rare plant with important medicinal and ornamental value. Aiming at the obvious differences between wild and cultivated populations of T. cuspidata from Northeast China, a total of 61 samples, that is, 33 wild yews and 28 cultivated yews were used to analyze the differences and correlations of the kinship, genetic diversity, and genetic structure between them by specific length amplified fragment sequencing (SLAF-seq). Finally, 470725 polymorphic SLAF tags and 58622 valid SNP markers were obtained. Phylogenetic analysis showed that 61 samples were classified into 2 clusters: wild populations and cultivated populations, and some wild yews were… More >

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