Edith O. Diovu1, Calister E. Ugwu2,*, Eunice N. Anaele3,*, Samuel WisdomofGod Uzondu4, Ogochukwu N. Umeh2, Iheanacho O. Enyum2, Kingsley C. Eze2, Godswill C. Onunkwo2, Anthony A. Attama5
Journal of Polymer Materials, Vol.43, No.2, 2026, DOI:10.32604/jpm.2026.077511
- 30 June 2026
Abstract Polymer-lipid hybrid-based solidified reverse micellar suspensions (SRMs) have gained increasing interest for topical drug delivery due to their ability to enhance solubility, stabilize bioactive compounds, and achieve sustained skin permeation. In this study, PEGylated SRMs were developed using a beeswax: Phospholipon 90H lipid matrix to enhance the solubility, stability, bioavailability, and wound-healing properties of a lipophilic extract of Calopogonium mucunoides (CM). PEG: lipid matrix ratios (1:0, 0:1, 1:1, 1:2, 1:3) were formulated and designated as CM1–CM5, with an unloaded matrix (CM6) as control. Physicochemical characterization included encapsulation efficiency (EE%), spreadability, pH, viscosity, Fourier transform infrared spectroscopy… More >