Iseult M. Browne^1,2, Monica Esteban Garcia^1,2, Alicia F. C. Okines^1,2,*

Oncology Research, Vol.34, No.10, 2026, DOI:10.32604/or.2026.082829 - 14 September 2026

Abstract Triple negative breast cancer (TNBC) is defined by the absence of oestrogen receptor, progesterone receptor, and HER2 expression, and carries a disproportionate burden of breast cancer-related mortality due to its aggressive biology and historically limited therapeutic options. The treatment landscape of metastatic TNBC has undergone a fundamental transformation over the past decade, driven by immune checkpoint inhibitors, antibody-drug conjugates (ADCs), and the identification of actionable genomic alterations. This review provides a comprehensive, clinically oriented appraisal of the current and emerging therapeutic landscape of metastatic TNBC, encompassing its molecular underpinnings and tumour microenvironment biology. We critically More >

Mariagrazia Piscione^1,*, Barbara Pala^2,3,*, Francesco Cribari³, Paola Gualtieri⁴, Dario Gaudio⁵, Marco Alfonso Perrone⁶, Laura Di Renzo⁴

Oncology Research, Vol.34, No.10, 2026, DOI:10.32604/or.2026.079215 - 14 September 2026

Abstract Cholesterol metabolism is central to cancer biology, influencing tumour initiation, progression, and therapeutic response, while contributing to the increased cardiovascular risk observed in cancer patients. Epidemiological studies investigating the relationship between circulating cholesterol levels and cancer risk have yielded conflicting results, reflecting substantial biological heterogeneity, tumour-specific metabolic demands, and methodological biases such as reverse causality. At the cellular level, malignant cells exhibit elevated cholesterol uptake and synthesis to sustain membrane biogenesis, lipid raft-dependent oncogenic signalling, and rapid proliferation. Cholesterol and its oxidized derivatives further modulate inflammation, angiogenesis, immune evasion, and key signalling pathways. Anticancer therapies… More >

Sri Suresh Mavuri¹, Surender Reddy Salkuti^2,*

Energy Engineering, Vol.123, No.10, 2026, DOI:10.32604/ee.2026.083940 - 30 August 2026

Abstract The operational flexibility and reliability of Multi-Microgrid (MMG) networks have been greatly increased by the growing adoption of Distributed Generation (DG) within the operational framework of the contemporary power infrastructure. Optimal location and size of DG units are, however, significant issues since the problem is complex, nonlinear, and multi-objective. A proposed study will develop a sophisticated optimization model using the Spider Wasp Optimization (SWO) algorithm to optimally allocate and size DGs in MMG systems. The goal of the proposed approach is to reduce essential economic goals, such as total operating cost, Levelized Cost of Energy… More > Graphic Abstract

Qianqian Peng, Fengjian He, Shumin Pan, Yinghua Ou^*

BIOCELL, Vol.50, No.9, 2026, DOI:10.32604/biocell.2026.081188 - 26 August 2026

Abstract Background: Nonalcoholic steatohepatitis (NASH) is a liver disease characterized by inflammation and fibrosis. Oridonin (Ori) exhibits anti-inflammatory and anti-fibrotic properties, but its role in NASH remains unclear. The study aimed to investigate whether Ori alleviates NASH injury by regulating pyroptosis through the nuclear factor-κB (NF-κB)/nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) axis. Methods: An in vitro NASH model was established in HepG2 cells using free fatty acids (FFA), and an in vivo model was induced in mice using a methionine-choline-deficient (MCD) diet. Biochemical assays, staining, flow cytometry, Western blot, and immunofluorescence assessed lipid accumulation, oxidative stress, inflammation, pyroptosis,… More > Graphic Abstract

Rongyu Yang¹, Qiaoxin Li², Hao Cheng^1,*, Rui Gao¹, Yongli Li^1,*

Energy Engineering, Vol.123, No.9, 2026, DOI:10.32604/ee.2026.082907 - 06 August 2026

Abstract The prediction of the steady-state performance of the electrolysis cell is not only crucial for evaluating the rationality of its design and operational benchmarks, but also provides an important foundation for understanding its dynamic response behavior. This paper presents an efficient data-driven method based on three-dimensional two-phase numerical simulation and machine learning (ML) to rapidly predict the steady-state performance of proton exchange membrane electrolysis cells (PEMEC) under multi-physics field coupling conditions. The framework is based on three key operating parameters—temperature, pressure, and inlet flow velocity. A polarization curve dataset was constructed through multi-condition numerical simulations,… More > Graphic Abstract

Yi Shen^1,2,3,#, Zeye Liu^4,#, Jing Xie^5,#, Xuanqi An^6,7,8,#, Zeyu Jing^1,2,3, Wenchuan Liao^1,2,3, Yifan Zhu^1,2,3, Chenyu Jiang^1,2,3, Xingliang Zhou^1,2,3, Xu Huang^1,2,3, Tianyu Liu^1,2,3, Jian Liu^1,2,3, Yuxi Ji^1,2,3, Yi Yan^1,3, Bei Feng^1,3, Yiwei Liu^1,2,3, Yi Shi^4,*, Yanjun Sun^2,*, Hao Zhang^1,2,3,*

Structural and Congenital Heart Disease, Vol.21, No.3, 2026, DOI:10.32604/schd.2026.085942 - 31 July 2026

Abstract Background: Congenital heart disease (CHD) is the most common congenital anomaly worldwide, yet the contribution of environmental factors to its global geographic variation remains incompletely understood. We aimed to systematically identify environmental factors associated with CHD incidence using an integrated framework combining machine learning and spatial epidemiology. Methods: Country-level data were obtained from the Global Burden of Disease (GBD) 2021 study. Boruta algorithm-based feature selection and random forest SHAP value ranking were applied to identify environmental factors associated with CHD incidence. Negative binomial regression was used to evaluate the associations between selected variables and CHD incidence.… More >

AL-Wesabi Ibrahim¹, Hassan M. Hussein Farh^2,*, Jiazhu Xu^1,*, Mohamad A. Alawad², Ahmed Alqurashi³, Abdullrahman A. Al-Shamma’a²

CMES-Computer Modeling in Engineering & Sciences, Vol.148, No.1, 2026, DOI:10.32604/cmes.2026.081371 - 27 July 2026

Abstract Load frequency control (LFC) in interconnected power systems has always been a challenging task in the presence of uncertainty and variability in the power systems arising primarily due to the integration of renewable energy sources and the impact of electric vehicles on the power system. Although various PI/PID and other advanced control strategies have been employed for LFC in power systems, the existing methods have shown some limitations in terms of dynamic flexibility and robustness in the presence of nonlinearities and couplings in the power systems. Moreover, the optimization methods employed for the tuning of… More >

Liang Li^1,#, Hong Deng^2,#, Zhiyong Li², Yu Li², Lingrui Liu², Lan Xie^2,*, Yue Chen^3,*

Oncology Research, Vol.34, No.8, 2026, DOI:10.32604/or.2026.081109 - 16 July 2026

Abstract Objectives: Oral squamous cell carcinoma (OSCC) is a common and deadly cancer affecting the oral cavity. This study aims to explore the regulatory role and molecular mechanism of miR-548ae-3p in OSCC proliferation, invasion, and lipid metabolism, as well as the therapeutic potential of isoliquiritigenin (ISL) targeting OSCC lipid metabolism. Methods: Expression levels of miR-548ae-3p were measured in OSCC cell lines and normal oral keratinocytes using real-time quantitative polymerase chain reaction. Functional assays, such as cell counting Kit-8 proliferation and Transwell invasion assays, evaluated the effects of miR-548ae-3p overexpression in CAL-27 and SCC-25 cells. Bioinformatic prediction and… More >

Edith O. Diovu¹, Calister E. Ugwu^2,*, Eunice N. Anaele^3,*, Samuel WisdomofGod Uzondu⁴, Ogochukwu N. Umeh², Iheanacho O. Enyum², Kingsley C. Eze², Godswill C. Onunkwo², Anthony A. Attama⁵

Journal of Polymer Materials, Vol.43, No.2, 2026, DOI:10.32604/jpm.2026.077511 - 30 June 2026

Abstract Polymer-lipid hybrid-based solidified reverse micellar suspensions (SRMs) have gained increasing interest for topical drug delivery due to their ability to enhance solubility, stabilize bioactive compounds, and achieve sustained skin permeation. In this study, PEGylated SRMs were developed using a beeswax: Phospholipon 90H lipid matrix to enhance the solubility, stability, bioavailability, and wound-healing properties of a lipophilic extract of Calopogonium mucunoides (CM). PEG: lipid matrix ratios (1:0, 0:1, 1:1, 1:2, 1:3) were formulated and designated as CM1–CM5, with an unloaded matrix (CM6) as control. Physicochemical characterization included encapsulation efficiency (EE%), spreadability, pH, viscosity, Fourier transform infrared spectroscopy… More >

Hooi Hung Tang, Te Meng Ting, Nur Syazreen Ahmad^*

CMES-Computer Modeling in Engineering & Sciences, Vol.147, No.3, 2026, DOI:10.32604/cmes.2026.080428 - 30 June 2026

Abstract In industrial and service robotics, autonomous mobile robots must achieve accurate trajectory tracking while maintaining low energy consumption to avoid frequent recharging and performance degradation. Energy efficiency is particularly critical because locomotion accounts for 45%–65% of total power consumption, directly limiting operational range and autonomy. This paper proposes an energy-aware trajectory tracking framework that optimizes a fractional-order proportional-integral-derivative (FOPID) controller using an Enhanced Whale Optimization Algorithm (E-WOA). The key contributions are threefold: (1) the E-WOA hybridizes Differential Evolution (DE)’s global exploration with WOA’s local exploitation to overcome premature convergence in high-dimensional FOPID parameter spaces; (2)… More >