Emrah Şişli^1,*, Pelin Köşger²

Congenital Heart Disease, Vol.20, No.4, pp. 531-537, 2025, DOI:10.32604/chd.2025.067271 - 18 September 2025

Abstract Residual atrioventricular valve regurgitation after correction of complete atrioventricular septal defect (cAVSD) is still not ideal. As a modification of the double-patch method, our technique comprises a suture-bite-wide strip of a third patch that is incorporated to the upper margin of the left side of the ventricular septal defect (VSD) patch. This third patch counteracts not only the valvular tissue loss caused by the suture bites but also the rightward displacement of the VSD patch in a bulged fashion that occurs with increased left ventricular pressure after weaning from cardiopulmonary bypass. This unfavorable outcome was More >

Prin Sungwan¹, Jutatip Panaampon^1,2, Ratchaneewan Sumankan^1,3, Genki Aoki¹, Seiji Okada^1,*

Oncology Research, Vol.33, No.9, pp. 2279-2307, 2025, DOI:10.32604/or.2025.065319 - 28 August 2025

Abstract Cholangiocarcinoma (CCA) is a fatal bile duct malignancy. CCA is intrinsically resistant to standard chemotherapy, responds poorly to it, and has a poor prognosis. Effective treatments for cholangiocarcinoma remain elusive, and a breakthrough in CCA treatment is still awaited. The human epidermal growth factor receptor 2 (HER2) plays an oncogenic role by promoting an aggressive cancer phenotype through multiple pathways. While HER2 has shown increasing potential as an effective target for breast and gastric cancers over the last decade, this has not been the case for CCA. This review explores the possibility of targeting HER2 More > Graphic Abstract

Xi Qin^1,#, Yulan Liu^1,#, Lin Zhu², Yunyan Mo¹, Jing Zhang³, Zhuchun Jiang⁴, Dongning Huang⁵, Xinrong Hu⁶, Jingzhang Li⁷, Quanfang Chen⁸, Feng Xue^1,*

Oncology Research, Vol.33, No.9, pp. 2451-2462, 2025, DOI:10.32604/or.2025.064119 - 28 August 2025

Abstract Background: The use of third-generation different tyrosine kinase inhibitors (TKIs) is considered the most effective option for treating advanced non-small cell lung cancer (aNSCLC) with epidermal growth factor receptor (EGFR) mutations. However, there is limited information on the efficacy and safety of aumolertinib in patients remains these cases. Methods: The clinical records of patients receiving aumolertinib as first-line therapy across four hospitals in the Guangxi Zhuang Autonomous Region from April 2020 to December 2021 were retrospectively analyzed, using progression-free survival (PFS) as the primary endpoint and overall survival (OS) representing the secondary endpoint. Adverse events… More >

Geetanjali Dei^1,2, Deepak Kumar Gupta¹, Binod Kumar Sahu², Amitkumar V. Jha³, Bhargav Appasani^3,*, Nicu Bizon^4,5,*

Energy Engineering, Vol.122, No.8, pp. 3399-3431, 2025, DOI:10.32604/ee.2025.067357 - 24 July 2025

Abstract This paper presents an innovative and effective control strategy tailored for a deregulated, diversified energy system involving multiple interconnected area. Each area integrates a unique mix of power generation technologies: Area 1 combines thermal, hydro, and distributed generation; Area 2 utilizes a blend of thermal units, distributed solar technologies (DST), and hydro power; and Third control area hosts geothermal power station alongside thermal power generation unit and hydropower units. The suggested control system employs a multi-layered approach, featuring a blended methodology utilizing the Tilted Integral Derivative controller (TID) and the Fractional-Order Integral method to enhance… More >

Jingdong Qi^1,#, Fei Zhang^1,#, Xia Zhang^2,*

Congenital Heart Disease, Vol.20, No.3, pp. 383-400, 2025, DOI:10.32604/chd.2025.064790 - 11 July 2025

Abstract Background: Congenital heart disease (CHD) remains a significant global health concern, with considerable heterogeneity across age groups, genders, and regions. Objective: This study aimed to investigate the global epidemiological patterns, inequalities, and socio-demographic determinants of CHD burden from 1990 to 2021 to inform targeted interventions. Methods: This study aimed to investigate the global epidemiological patterns, inequalities, and socio-demographic determinants of CHD burden from 1990 to 2021 to inform targeted interventions. Results: CHD burden increased with age, peaking among individuals aged 70 years and older. This does not reflect new-onset disease, but rather the accumulation of late diagnoses,… More >

Wilhelm Mistiaen^*

Congenital Heart Disease, Vol.20, No.3, pp. 305-323, 2025, DOI:10.32604/chd.2025.064675 - 11 July 2025

Abstract The presence of a bicuspid aortic valve (BAV) is the most common congenital heart anomaly, which can remain asymptomatic for decades, if it is not a part of a syndrome, such as Turner syndrome or genetic connective tissue disorders. There are several classifications for BAV, each with its advantages and drawbacks. The condition can lead to valvular malfunction such as regurgitation and stenosis, but is often associated with dilatation of the aortic root, the ascending aorta, the aortic arch, or a combination. Altered flow patterns due to the valve dysfunction as well as the breakdown… More >

Amani Baazeem¹, Muhammad Shoaib Arif^2,*, Yasir Nawaz³, Kamaleldin Abodayeh²

CMES-Computer Modeling in Engineering & Sciences, Vol.143, No.3, pp. 3463-3489, 2025, DOI:10.32604/cmes.2025.066299 - 30 June 2025

Abstract The numerical approximation of stochastic partial differential equations (SPDEs), particularly those including q-diffusion, poses considerable challenges due to the requirements for high-order precision, stability amongst random perturbations, and processing efficiency. Because of their simplicity, conventional numerical techniques like the Euler-Maruyama method are frequently employed to solve stochastic differential equations; nonetheless, they may have low-order accuracy and lower stability in stiff or high-resolution situations. This study proposes a novel computational scheme for solving SPDEs arising from a stochastic SEIR model with q-diffusion and a general incidence rate function. A proposed computational scheme can be used to… More >

Mohammed Althubyani^1,*, Nidal E. Taha², Khdija O. Taha², Rasmiyah A. Alharb², Sayed Saber^1,3

CMES-Computer Modeling in Engineering & Sciences, Vol.143, No.3, pp. 3491-3521, 2025, DOI:10.32604/cmes.2025.061640 - 30 June 2025

Abstract This study investigates the dynamics of pneumococcal pneumonia using a novel fractal-fractional Susceptible-Carrier-Infected-Recovered model formulated with the Atangana-Baleanu in Caputo (ABC) sense. Unlike traditional epidemiological models that rely on classical or Caputo fractional derivatives, the proposed model incorporates nonlocal memory effects, hereditary properties, and complex transmission dynamics through fractal-fractional calculus. The Atangana-Baleanu operator, with its non-singular Mittag-Leffler kernel, ensures a more realistic representation of disease progression compared to classical integer-order models and singular kernel-based fractional models. The study establishes the existence and uniqueness of the proposed system and conducts a comprehensive stability analysis, including local More >

Liqiong Chen¹, Jie Pang¹, Kai Zhang^1,*, Juemei Pang², Haonan Liu³, Quan Fang¹

Structural Durability & Health Monitoring, Vol.19, No.4, pp. 937-952, 2025, DOI:10.32604/sdhm.2025.063177 - 30 June 2025

Abstract In order to reduce the ecological environmental pollution and economic losses caused by oil spill accidents from cross-river oil pipelines, this paper studies the structures of oil containment booms used for intercepting oil spills in rapid rivers and proposes a new type of double-layer hole oil containment boom. By establishing a solid mechanics model, the geometric deformation and stress-strain distribution patterns of the double-layer hole oil containment boom under rapid flow velocities were analyzed. Additionally, the impact of the skirt angle, hole size, and porosity on the mechanical properties of the new oil containment boom More >

KHANH TOAN NGUYEN^*, THI HUONG PHAM, VAN LAM NGO, VAN TUAN BUI, VAN NHAT NGUYEN, THI PHUONG THAO NGUYEN, THI KHANH HA NGUYEN, THI THUY VAN NGUYEN

Oncology Research, Vol.33, No.7, pp. 1667-1677, 2025, DOI:10.32604/or.2025.061905 - 26 June 2025

Abstract Aims: The study aimed to evaluate the effectiveness and adverse events of tyrosine kinase inhibitors (TKIs) in the first-line treatment of advanced non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutations. Methods: A retrospective study on advanced NSCLC patients with EGFR mutations treated with TKIs as a first-line therapy at Nghe An Oncology Hospital, Vietnam between January 2017 and August 2023. The primary endpoints included objective response rate, progression-free survival, and tolerability. The secondary endpoint was overall survival. Results: A total of 211 patients received first-line treatment with Erlotinib (n = 74), Gefitinib (n… More >