Chunliu He¹, Jiaqiu Wang², Yuxiang Huang¹, Tongjing Zhu¹, Yuehong Miao¹, Zhiyong Li^1,2*

Molecular & Cellular Biomechanics, Vol.13, No.1, pp. 23-36, 2016, DOI:10.3970/mcb.2016.013.027

Abstract Fibrous cap thickness (FCT) is seen as critical to plaque vulnerability. Therefore, the development of automatic algorithms for the quantification of FCT is for estimating cardiovascular risk of patients. Intravascular optical coherence tomography (IVOCT) is currently the only in vivo imaging modality with which FCT, the critical component of plaque vulnerability, can be assessed accurately. This study was aimed to discussion the correlation between the texture features of OCT images and the FCT in lipid-rich atheroma. Methods: Firstly, a full automatic segmentation algorithm based on unsupervised fuzzy c means (FCM) clustering with geometric constrains was developed to segment the ROIs… More >

Y. Gür^*

Molecular & Cellular Biomechanics, Vol.11, No.4, pp. 249-258, 2014, DOI:10.3970/mcb.2014.011.249

Abstract The purpose of the study presented here was to investigate the manufacturability of human anatomical models from Computed Tomography (CT) scan data via a 3D desktop printer which uses fused deposition modelling (FDM) technology. First, Digital Imaging and Communications in Medicine (DICOM) CT scan data were converted to 3D Standard Triangle Language (STL) format by using InVaselius digital imaging program. Once this STL file is obtained, a 3D physical version of the anatomical model can be fabricated by a desktop 3D FDM printer. As a case study, a patient’s skull CT scan data was considered, and a tangible version of… More >

Colin K. Choi^*, Brian P. Helmke^∗,†

Molecular & Cellular Biomechanics, Vol.5, No.4, pp. 247-258, 2008, DOI:10.3970/mcb.2008.005.247

Abstract Hemodynamic shear stress guides a variety of endothelial phenotype characteristics, including cell morphology, cytoskeletal structure, and gene expression profile. The sensing and processing of extracellular fluid forces may be mediated by mechanotransmission through the actin cytoskeleton network to intracellular locations of signal initiation. In this study, we identify rapid actin-mediated morphological changes in living subconfluent and confluent bovine aortic endothelial cells (ECs) in response to onset of unidirectional steady fluid shear stress (15 dyn/cm²). After flow onset, subconfluent cells exhibited dynamic edge activity in lamellipodia and small ruffles in the downstream and side directions for the first 12 min; activity… More >

Yong Gan^*, Zhen Chen^∗,†

Molecular & Cellular Biomechanics, Vol.3, No.3, pp. 89-94, 2006, DOI:10.3970/mcb.2006.003.089

Abstract Due to their nanoscale size and special features, carbon nanotubes could enter the human body via certain way. The growing use of carbon nanotubes in practical applications, hence, prompts a necessity to study the potential health risks of carbon nanotubes. A numerical study is performed in this paper to investigate the size effect of carbon nanotubes on the bulk modulus of a lipid bilayer by using the constant surface tension molecular dynamics simulation procedure. It is found that the size effect is not monotonic with the increase of nanotube length. An explanation is given on the basis of the atomic… More >

Qianxin Wang^1,2,3, Chao Hu^1,2,*, Ya Mao^1,2

CMES-Computer Modeling in Engineering & Sciences, Vol.117, No.3, pp. 509-525, 2018, DOI:10.31614/cmes.2018.04098

Abstract Designing the optimal distribution of Global Navigation Satellite System (GNSS) ground stations is crucial for determining the satellite orbit, satellite clock and Earth Rotation Parameters (ERP) at a desired precision using a limited number of stations. In this work, a new criterion for the optimal GNSS station distribution for orbit and ERP determination is proposed, named the minimum Orbit and ERP Dilution of Precision Factor (OEDOP) criterion. To quickly identify the specific station locations for the optimal station distribution on a map, a method for the rapid determination of the selected station locations is developed, which is based on the… More >

T. V. Viknesh¹, V. Manik,an

CMES-Computer Modeling in Engineering & Sciences, Vol.113, No.1, pp. 109-116, 2017, DOI:10.3970/cmes.2017.113.107

Abstract The working of Canonical switching cell (CSC) converter was studied and its equivalent circuit during ON and OFF states were obtained. State space model of CSC converter in ON and OFF states were developed using the Kirchhoff laws. The state space matrices were used to construct the transfer functions of ON & OFF states. The step response of the converter was simulated using MATLAB. The step response curve was obtained using different values of circuit components (L, C1, C2 and RL)and optimized. The characteristic parameters such as rise time, overshoot, settling time, steady state error and stability were determined using… More >

C.V. Nastos, T.C. Theodosiou, C.S. Rekatsinas, D.A. Saravanos¹

CMES-Computer Modeling in Engineering & Sciences, Vol.107, No.5, pp. 379-409, 2015, DOI:10.3970/cmes.2015.107.379

Abstract A computationally efficient numerical method is developed for the prediction of transient response in orthotropic rod and beam structures. The method takes advantage of the outstanding properties of compactly supported Daubechies wavelet scaling functions for the spatial approximation of displacements in a finite domain of the structure, hence is termed Finite Wavelet Domain (FWD) method. The basic principles and advantages of the method are presented and the discretization of the equations of motion is formulated for one-dimensional structures. Numerical results for the simulation of propagating guided waves in rods and strips are presented and compared against traditional finite elements. More >

K.W. Luczynski¹, A. Dejaco¹, O. Lahayne¹, J. Jaroszewicz², W.Swieszkowski², C. Hellmich¹

CMES-Computer Modeling in Engineering & Sciences, Vol.87, No.6, pp. 505-529, 2012, DOI:10.3970/cmes.2012.087.505

Abstract A 71 volume-% macroporous tissue engineering scaffold made of poly-l-lactide (PLLA) with 10 mass-% of pseudo-spherical tri-calcium phosphate (TCP) inclusions (exhibiting diameters in the range of several nanometers) was microCT-scanned. The corresponding stack of images was converted into regular Finite Element (FE) models consisting of around 100,000 to 1,000,000 finite elements. Therefore, the attenuation-related, voxel-specific grey values were converted into TCP-contents, and the latter, together with nanoindentation tests,entered a homogenization scheme of the Mori-Tanaka type, as to deliver voxel-specific (and hence, finite element-specific) elastic properties. These FE models were uniaxially loaded, giving access to the macroscopic Young's modulus of the… More >

S. Ullah¹, B. Pichler¹, S. Scheiner^1,2, C. Hellmich^1,3

CMES-Computer Modeling in Engineering & Sciences, Vol.57, No.3, pp. 279-316, 2010, DOI:10.3970/cmes.2010.057.279

Abstract Point-wise optical measurements of 3D displacement vectors over time are a key input for monitoring shotcrete tunnel shells during construction according to the New Austrian Tunnelling Method (NATM). Aiming at estimation of the stresses prevailing in the highly loaded, hydrating material, we here deal with two different interpolation strategies for reconstructing, from measured displacement vectors, the 3D displacement field histories of the inner surface of the tunnel shell. The first approach considers spatial interpolation of displacement components in a fixed Cartesian base frame, while the second (new) approach refers to displacement components in a moving base frame consisting of vectors… More >

Mahesh S. Shinde^1,*, Kishor M. Ashtankar¹

CMC-Computers, Materials & Continua, Vol.54, No.3, pp. 287-306, 2018, DOI:10.3970/cmc.2018.054.287

Abstract Cooling system improvement is important in injection molding to get better quality and productivity. The aim of this paper was to compare the different shapes of the conformal cooling channels (CCC) with constant surface area and CCC with constant volume in injection molding using Mold-flow Insight 2016 software. Also the CCC results were compared with conventional cooling channels. Four different shapes of the CCC such as circular, elliptical, rectangular and semi-circular were proposed. The locations of the cooling channels were also kept constant. The results in terms of cooling time, cycle time reduction and improvement in quality of the product… More >