Fuyao Yan^{1, #}, Yu hin Chan^2,#, Abhinav Saboo³ , Jiten Shah⁴, Gregory B. Olson^{1, 3}, Wei Chen^{2, *}

CMES-Computer Modeling in Engineering & Sciences, Vol.117, No.3, pp. 343-366, 2018, DOI:10.31614/cmes.2018.04452

Abstract Predicting the mechanical properties of additively manufactured parts is often a tedious process, requiring the integration of multiple stand-alone and expensive simulations. Furthermore, as properties are highly location-dependent due to repeated heating and cooling cycles, the properties prediction models must be run for multiple locations before the part-level performance can be analyzed for certification, compounding the computational expense. This work has proposed a rapid prediction framework that replaces the physics-based mechanistic models with Gaussian process metamodels, a type of machine learning model for statistical inference with limited data. The metamodels can predict the varying properties within an entire part in… More >

Warren D. Marcus^1,2, Rodger P. McEver³, Cheng Zhu¹

Molecular & Cellular Biomechanics, Vol.1, No.4, pp. 245-252, 2004, DOI:10.3970/mcb.2004.001.245

Abstract When a cell adhered to another cell or substratum via surface proteins is forced to detach, lipid membrane tethers are often extruded from the cell surface before the protein bond dissociates. For example, during the inflammatory reaction leukocytes roll on the surface of activated endothelial cells. The rolling adhesion is mediated by interactions of selectins with their ligands, e.g., P-selectin glycoprotein ligand (PSGL)-1, which extrudes membrane tethers from the surfaces of both leukocytes and endothelial cells. Membrane tether extrusion has been suggested to regulate leukocyte rolling. Here we examine several factors that may affect forces required to initiate membrane tethers,… More >

Wen JING^1,§, Chuanfen LI^2,3,§, Yingli LU⁴, Lianshi FENG⁴

BIOCELL, Vol.43, No.3, pp. 129-138, 2019, DOI:10.32604/biocell.2019.06087

Abstract This study aimed to investigate the microRNA expression profile and the characteristics of lipid metabolism in the livers of rats undergoing a high-fat diet. Fifty male Sprague-Dawley (SD) rats were divided into a standard chow group (C group, N = 10) and a high-fat diet group (H group, N = 40). After 12 weeks, the rat body weight, body length, fat mass, and serum lipid concentration were measured. The expression profile of microRNAs and the gene and protein expression levels involved in lipid metabolism in rat liver were detected. Body fat and serum lipid concentrations were all significantly higher in… More >

Sheng Sun, Joseph T. Y. Wong, Tong-Yi Zhang

The International Conference on Computational & Experimental Engineering and Sciences, Vol.17, No.2, pp. 47-48, 2011, DOI:10.3970/icces.2011.017.047

Abstract Micro/nano structures formed via self-assembly of biological macromolecules, such as DNA and RNA, have potential applications as building units in micro/nano/bio-devices. The self-assembled structures of biological macromolecules can be manipulated by applying electric field. Here we demonstrate such manipulation by using coarse-grained molecular dynamics simulations. Starting from randomly distributed CG DOPE lipids and polarizable water molecules, we studied the self-assembled structures in different hydration levels of lipid (the number of water molecules per lipid) and different strength of external electric fields. When the hydration level of lipid was 24 water per lipid (w/l) or 36 w/l, the self-assembled structures were… More >

Darrell W. Pepper¹, Xiuling Wang²

The International Conference on Computational & Experimental Engineering and Sciences, Vol.13, No.1, pp. 15-22, 2009, DOI:10.3970/icces.2009.013.015

Abstract A meshless method for simulating indoor contaminant dispersion within buildings and rooms has been developed. The approach utilizes the advantages of the meshless method by distributing collocation points and different order radial basis functions according to the computational domain and evolving numerical solution. The numerical scheme yields fast convergence and high accuracy necessary for providing quick assessments of contamination transport within enclosures. More >

Weiming Tao¹, Xingwang Yang¹

The International Conference on Computational & Experimental Engineering and Sciences, Vol.12, No.3, pp. 83-84, 2009, DOI:10.3970/icces.2009.012.083

Abstract Laser controlled separation of brittle materials like glass is a promising non-conven\discretionary {-}{}{}tional cutting method. It is an application of the crack propagation driven by thermal stresses induced by laser irradiation. In order to induce and control a crack propagating accurately along predetermined asymmetric trajectory in a brittle plate, an iterative method for effective laser scanning path was presented, and the effect of control parameters on the convergence was investigated. The iterative formulation for laser scanning path was based on PID control theory, which was composed of deviation of the crack from predetermined trajectory and its integral and differential. To… More >

T. Aizawa¹, H. Akebono², H.Suzuki¹

The International Conference on Computational & Experimental Engineering and Sciences, Vol.5, No.4, pp. 193-198, 2008, DOI:10.3970/icces.2008.005.193

Abstract In order to achieve power transmission parts like a compact gearwheel which indicates high performance properties, hybrid surface modification was performed by combining Super Rapid Induction Heating & Quenching(SRIQ) which creates high fatigue strength and Diamond Like Carbon (DLC) coating which are well known for their high hardness, low friction and excellent wear resistance. And, in order to prevent the base material from decreasing its fatigue strength, DLC was coated by using Unbalanced Magnetron Sputtering (UBMS) method which can coat at low temperature. Rotational bending fatigue tests and friction-wear tests were carried out. It was clear that it is possible… More >

U.Suryanarayana Murty¹, V.Sreehari Rao²

The International Conference on Computational & Experimental Engineering and Sciences, Vol.5, No.2, pp. 121-128, 2008, DOI:10.3970/icces.2008.005.121

Abstract Artificial intelligence has opened a new window of opportunity and has definitely a long way to look ahead in\nobreakspace {}area of data analysis. The enormity of magnitude of data and its complex nature often perplex the epidemiologists. This is especially true in case of vector borne diseases where a timely and precise understanding of disease during decision making process comes handy for curbing the diseases in event of an outbreak or epidemic. Often the public health officials feel the need of correct identification of true positive cases. A tool that classify disease according to presence or absence of a disease… More >

Caili Li^{1, §}, Christopher Baird², Jing Yao³, Chun Yang⁴, Liang Wang⁵, Han Yu⁵, Tal Geva⁶, Dalin Tang^{5*, 7, §}

CMES-Computer Modeling in Engineering & Sciences, Vol.119, No.1, pp. 227-244, 2019, DOI:10.32604/cmes.2019.06036

Abstract Pulmonary valve stenosis (PVS) is one common right ventricular outflow tract obstruction problem in patients with tetralogy of Fallot (TOF). Congenital bicuspid pulmonary valve (BPV) is a condition of valvular stenosis, and the occurrence of congenital BPV is often associated with TOF. Dynamic computational models of normal pulmonary root (PR) with tri-leaflet and PR with BPV in patients with TOF were developed to investigate the effect of geometric structure of BPV on valve stress and strain distributions. The pulmonary root geometry included valvular leaflets, sinuses, interleaflet triangles and annulus. Mechanical properties of pulmonary valve leaflet were obtained from biaxial testing… More >

Shegufta Shetranjiwalla, Shaojun Li, Laziz Bouzidi, Suresh S. Narine^*

Journal of Renewable Materials, Vol.5, No.5, pp. 333-344, 2017, DOI:10.7569/JRM.2017.634102

Abstract The impact of polymerization protocol on phase structure and properties of entirely lipid-derived thermoplastic poly(ester urethane)s (TPEU)s was investigated. The TPEUs were synthesized from 1,7-heptamethylene diisocyanate, polyester diols and 1,9-nonanediol (ND) as chain extender. A two-stage polymerization method was used to prepare two TPEUs; one in which ND was added in the first stage of polymerization as part of the prepolymer and another in the second stage after the prepolymer was formed. Two very different morphologies exhibiting different degrees of phase separation were obtained, driven by the sequence of addition of the chain extender. The incorporation of the chain extender… More >