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The Correlation Between Texture Features and Fibrous Cap Thickness of Lipid-Rich Atheroma Based on Optical Coherence Tomography Imaging

Chunliu He1, Jiaqiu Wang2, Yuxiang Huang1, Tongjing Zhu1, Yuehong Miao1, Zhiyong Li1,2*

1 Department of Biomedical Engineering, College of Biological Science and Medical Engineering, Southeast University, No. 2, Sipailou Street, Xuanwu District, Nanjing, 210000, Jiangsu Province, China.
2 School of Chemistry, Physics and Mechanical Engineering, Science and Engineering Faculty, Queensland University of Technology, 2 George St, Brisbane City, QLD 4000, Australia.
* Corresponding author: Zhiyong Li,

Molecular & Cellular Biomechanics 2016, 13(1), 23-36.


Fibrous cap thickness (FCT) is seen as critical to plaque vulnerability. Therefore, the development of automatic algorithms for the quantification of FCT is for estimating cardiovascular risk of patients. Intravascular optical coherence tomography (IVOCT) is currently the only in vivo imaging modality with which FCT, the critical component of plaque vulnerability, can be assessed accurately. This study was aimed to discussion the correlation between the texture features of OCT images and the FCT in lipid-rich atheroma. Methods: Firstly, a full automatic segmentation algorithm based on unsupervised fuzzy c means (FCM) clustering with geometric constrains was developed to segment the ROIs of IVOCT images. Then, 32 features, which are associated with the structural and biochemical changes of tissue, were carried out to describe the properties of ROIs. The FCT in grayscale IVOCT images were manually measured by two independent observers. In order to analysis the correlation between IVOCT image features and manual FCT measurements, linear regression approach was performed. Results: Inter-observer agreement of the twice manual FCT measurements was excellent with an intraclass correlation coefficient (ICC) of 0.99. The correlation coefficient between each individual feature set and mean FCT of OCT images were 0.68 for FOS, 0.80 for GLCM, 0.74 for NGTDM, 0.72 for FD, 0.62 for IM and 0.58 for SP. The fusion image features of automatic segmented ROIs and FCT measurements improved the results significantly with a high correlation coefficient (r= 0.91, p<0.001). Conclusion The OCT images features demonstrated the perfect performances and could be used for automatic qualitative analysis and the identification of high-risk plaques instead manual FCT measurements.


Cite This Article

He, C., Wang, J., Huang, Y., Zhu, T., Miao, Y. et al. (2016). The Correlation Between Texture Features and Fibrous Cap Thickness of Lipid-Rich Atheroma Based on Optical Coherence Tomography Imaging. Molecular & Cellular Biomechanics, 13(1), 23–36.

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