Fang Chen*, Dongqiang Yang†, Yuhua Ru‡, Shan Cao*, Aishe Gao*
Oncology Research, Vol.27, No.6, pp. 691-701, 2019, DOI:10.3727/096504018X15426763753594
Abstract Escalating evidence suggests that microRNA-101 (miR-101) is implicated in the development and progression of various cancers, including papillary thyroid carcinoma (PTC). However, the biological function and
molecular mechanisms of miR-101 in PTC are still unclear. In this study, we demonstrated that miR-101
expression was significantly decreased in PTC tissues and cell lines. Clinically, a low level of miR-101 was
positively associated with advanced histological stages and lymph node and distant metastases. The expression
of CXCL12 was negatively correlated with miR-101 level in PTC. CXCL12 was validated as a direct target
of miR-101 in PTC cells. Functional experiments proved that miR-101… More >
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