HAZAEL RAMIRO CEJA-GALVEZ1, ERANDIS DHENI TORRES-SÁNCHEZ1, JUAN HERIBERTO TORRES-JASSO2, EMMANUEL REYESURIBE1, JOEL SALAZAR-FLORES1,*
BIOCELL, Vol.45, No.5, pp. 1241-1250, 2021, DOI:10.32604/biocell.2021.015771
Abstract Paraoxonase-1 (PON-1) is an enzyme that hydrolyzes organophosphate pesticides. The presence of
polymorphisms in PON-1 (L55M and Q192R) decreases its enzyme activity and increases the risk of central nervous
system (CNS) toxicity in occupationally exposed farmers, leading to chronic degenerative diseases and death. We
studied 103 farmers in the region of Cienega Jalisco, Mexico, which were exposed mainly to organophosphate
pesticides. We used serum and plasma samples to assay PON-1 activity and perform polymorphism analysis (L55M
and Q192R) using qPCR and TaqMan probes, respectively. For both polymorphisms, there was high percentage of
heterozygosity (55 LL = 0.19, LM = 0.75,… More >
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