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    Trypanosoma cruzi invasion in non-phagocytic cells: an ultrastructural study

    Juan Agustín CUETO3, Emile SANTOS BARRIAS6, Wanderley de SOUZA4, 5, Patricia Silvia ROMANO1, 2

    BIOCELL, Vol.42, No.3, pp. 105-108, 2018, DOI:10.32604/biocell.2018.07017

    Abstract Trypanosoma cruzi is the causative agent of Chagas disease. This parasite requires the intracellular niche in order to proliferate and disseminate the infection. After invasion, T. cruzi resides temporarily in an acidic vacuole which is lysed by a not well-understood mechanism. Transmission electron microscopy was used to describe the process of T. cruzi escape from the parasitophorous vacuole over the time. Using HeLa (non-professional phagocytic cells) as host cell, we observed that recently internalized parasites reside in a membrane-bounded vacuole. A few hours later, the first sign of vacuole disruption appeared as membrane discontinuities. This observation was followed More >

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