JIAWEI FU1,2,3,#, CHUNSHUAI WU1,2,3,#, GUANHUA XU1,2,3, JINLONG ZHANG1, YIQIU LI1, CHUNYAN JI1,2,3, ZHIMING CUI1,2,3,*
BIOCELL, Vol.47, No.4, pp. 739-749, 2023, DOI:10.32604/biocell.2023.026881
Abstract Spinal cord injury (SCI), a complex neurological disorder, triggers a series of devastating neuropathological events such as ischemia, oxidative stress, inflammatory events, neuronal apoptosis, and motor dysfunction. However, the classical necrosome, which consists of receptor-interacting protein (RIP)1, RIP3, and mixed-lineage kinase domain-like protein, is believed to control a novel type of programmed cell death called necroptosis, through tumour necrosis factor-alpha/tumour necrosis factor receptor-1 signalling or other stimuli. Several studies reported that necroptosis plays an important role in neural cell damage, release of intracellular pro-inflammatory factors, lysosomal dysfunction and endoplasmic reticulum stress. Recent research indicates that necroptosis is crucial to the… More >
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