GIUSEPPE STEFANO NETTI1,*, FEDERICA SPADACCINO1, VALERIA CATALANO1, GIUSEPPE CASTELLANO2, GIOVANNI STALLONE3, ELENA RANIERI1
BIOCELL, Vol.46, No.10, pp. 2235-2239, 2022, DOI:10.32604/biocell.2022.020209
Abstract Pentraxin-3 (PTX3), the prototype of long pentraxins, seems to influence complement system (CS) modulation.
PTX3 and CS sustain carcinogenesis, enriching tumor microenvironment (TME) with pro-inflammatory molecules
promoting angiogenesis in prostate cancer (PC) and renal cell carcinoma (RCC). Furthermore, cancer cells
overexpress complement regulatory proteins, such as CD46, CD55 and CD59, which negatively affect complement
pathways for support cancer cells survival. This viewpoint aims to elucidate the ambivalent role of PTX3 and the CS
in the context of tumor microenvironment (TME). More >
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