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    HAND2-AS1, PRKAA2 and VLDLR predict the risk of peritoneal metastasis in gastric cancer of different Lauren types based on STEPP analysis

    HUI QU1,2,3,4,#, RUICHUAN SHI1,2,3,4,#, BOWEN YANG1,2,3,4, XI CHEN1,2,3,4, YUJIA SONG1,2,3,4, LINGZI HE1,2,3,4, YITING SUN1,2,3,4, YUJING YANG1,2,3,4, ZHI LI1,2,3,4,*, XIUJUAN QU1,2,3,4,*

    BIOCELL, Vol.46, No.3, pp. 721-735, 2022, DOI:10.32604/biocell.2021.015867

    Abstract The peritoneum is the most common site of recurrence of gastric cancer (GC). Early occult peritoneal metastasis is difficult to detect by imaging examination. Stratifying the risk of peritoneal metastasis in patients with different Lauren subtypes is of great clinical value. We performed a univariate Cox regression to identify those genes with prognostic value of overall survival (OS) and peritoneal-specified disease-free survival (psDFS) from the Gene Expression Omnibus database. The candidate genes were screened by the Subpopulation Treatment Effect Pattern Plot (STEPP) method. Propensity score matching (PSM) analysis was used to reduce the interference of confounders on the results. Based… More >

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