JIAYING QIU¹, YAN CHANG⁵, WENPENG LIANG¹, MENGSI LIN¹, HUI XU², WANQING XU⁴, QINGWEN ZHU¹, HAIBO ZHANG^3,*, ZHENYU ZHANG^1,*

BIOCELL, Vol.47, No.11, pp. 2351-2359, 2023, DOI:10.32604/biocell.2023.031043

Abstract Denervation-induced skeletal muscle atrophy can potentially cause the decline in the quality of life of patients and an increased risk of mortality. Complex pathophysiological mechanisms with dynamic alterations have been documented in skeletal muscle atrophy resulting from innervation loss. Hence, an in-depth comprehension of the key mechanisms and molecules governing skeletal muscle atrophy at varying stages, along with targeted treatment and protection, becomes essential for effective atrophy management. Our preliminary research categorizes the skeletal muscle atrophy process into four stages using microarray analysis. This review extensively discusses the pathways and molecules potentially implicated in regulating the four stages of denervation… More >

WEI LI^1,2, YUEYANG DUAN¹, XIAOTONG YAN¹, XIANGXIANG LIU¹, MEILING FAN^3,*, ZI WANG^1,2,*

BIOCELL, Vol.46, No.6, pp. 1417-1423, 2022, DOI:10.32604/biocell.2022.017609

Abstract Ginsenoside Rb3 (G-Rb3) is one of the primary active compounds isolated from Panax ginseng Meyer, which belongs to protopanaxadiol ginsenosides (PPD). Based on the structure-activity relationship (SAR) of ginsenosides, the pentose structure of G-Rb3 limited itself to possess more pharmacological activity to a certain extent. However, pharmacokinetics show that G-Rb3 is processed through deglycosylation in the intestinal tract and converted into more active rare saponins, such as Compound K, F2, etc. A series of studies focused on neuroprotection and the cardiovascular system demonstrating its therapeutic potentials, which was achieved by diminishing oxidative stress and apoptosis. Therefore, more systematic and in-depth… More >