MENGSHU ZHAO1, PINGSHI GAO1, LIANG TAO1, JINGJING WEN1, LEI WANG1, YUGUO YI1, YUXIN CHEN2, JUNSONG WANG1, XI XU1, JIANFA ZHANG1, DAN WENG1,*
BIOCELL, Vol.44, No.3, pp. 353-361, 2020, DOI:10.32604/biocell.2020.08955
Abstract As a natural analog of resveratrol, piceatannol (Pic) exhibits good antioxidant and anti-inflammatory activities in
different disease models. However, the role of Pic in type 1 diabetes mouse model has not been reported yet. In this study, we
investigated the in vivo effect of Pic in streptozotocin (STZ)-induced type 1 diabetic mice. Mice were injected with STZ to
establish the type 1 diabetes mellitus (T1DM) model. After stable hyperglycemia was achieved, mice were then orally treated
with Pic (40 mg/kg b.w., i.g.) for 30 days. The results indicated that Pic supplementation efficiently alleviated the typical
symptoms associated with T1DM, including… More >
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