BINGJIE WANG1, YEWEN ZHOU1,2,3, TONGJUAN NIU1, MENGQING YIN1, SHENG CUI1,2,3,*
BIOCELL, Vol.48, No.2, pp. 327-338, 2024, DOI:10.32604/biocell.2023.044630
Abstract Introduction: The regulation of thyroid-stimulating hormone (TSH) synthesis involves neurotransmitters, with melatonin being a subject of ongoing debate. TSH transcription, synthesis, and secretion from the pituitary pars distalis (PD) is primarily regulated in a photoperiodic manner by thyrotropin-releasing hormone (TRH). In contrast, in the pituitary pars tuberalis (PT), mRNA transcription and alpha/beta chain synthesis, but not secretion, of a TSH-like product is regulated by melatonin. Conversely, non-photoperiodic melatonin might also affect the secretion of a TSH-like product from the PT. Nevertheless, the impact of exogenous melatonin on the underlying PD-TSH synthesis remains unclear. Casein kinase 1α (CK1α) plays a negative… More >
Login
Register
