MIN CHEN1,#, YUAN HUANG2,#, WEN XU2, CHUNLIN SU2,*
BIOCELL, Vol.46, No.6, pp. 1505-1519, 2022, DOI:10.32604/biocell.2022.016564
Abstract The development of polycystic ovary syndrome (PCOS) is closely related to the chronic inflammatory and
obese. Recent studies have found macrophages regulate the chronic inflammation and adipose tissue remodelling, but
the underlying mechanisms have not been clarified. In this study, we established a model of PCOS in the offspring
rats by high androgen exposure during late pregnancy in parental and established a female rat macrophage
eliminating model by rejection of clodronate liposome. Then, the offspring rat macrophage phenotype in offspring
female rat adipose tissue, and levels of testosterone, angiogenic factors (PDGF and VEGF) and inflammatory factors
(TNF-α and MCP-1) were… More >
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