Solenne Mondésert-Deveraux1, *, Rachele Allena2, Denis Aubry1
Molecular & Cellular Biomechanics, Vol.15, No.3, pp. 155-176, 2018, DOI: 10.3970/mcb.2018.03053
Abstract Cell migration is the cornerstone of many biological phenomena such as cancer metastasis, immune response or organogenesis. Adhesion-based motility is the most renown and examined motility mode, but in an adhesion-free confined environment or simply to achieve a higher migration speed, cells can adopt a very interesting bleb-based migration mode called “chimneying”. This mode rests on the sharp synchronization between the active contraction of the cells uropod and the passive friction force between the cell and the confining surface. In this paper, we propose a one dimensional poroelastic model of chimneying which considers the active strains of the cell, but,… More >
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